Evidence map›Paper›PMID 31455860›Full record

ReviewMolecular psychiatry2020

Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation.

Henry W Chase, Megan A Boudewyn, Cameron S Carter, Mary L Phillips

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562387 (Transcranial Direct Current Stimulation), which is not on this map. Cited by 151 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 13 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06562387 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Transcranial Direct Current Stimulation (tDCS) as Adjunctive Therapy to Cognitive Stimulation in Medical Students With Depression

TypeinterventionalSponsorUniversidad Nacional Autonoma de MexicoRan2024 to 2025Enrolled60ConditionsClinical TrialArmstranscranial direct current stimulation, cognitive stimulation, sham transcranial direct current stimulation
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 13 syntheses or guidelines pooled it, 264 citations in OpenAlex.

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  10. Evidence-based umbrella review of cognitive effects of prefrontal tDCS.Social cognitive and affective neuroscience · 2022
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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Henry W ChaseDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. chaseh@upmc.edu.
Megan A BoudewynDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
Cameron S CarterDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
Mary L PhillipsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
University of California, Davis · USUniversity of Pittsburgh · US

Funding

Modulation of ventrolateral prefrontal cortical activity during reward processing by transcranial direct current stimulationR21MH108421 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHASE, HENRY, PHILLIPS, MARY LOUISE · 2016 to 2017
$381k
NIMH NIH HHS R21 MH108421
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify key priorities for future research into major depression and schizophrenia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the establishment of the cognitive impact of tDCS, as well as investigations of the potential clinical efficacy of tDCS. We highlight areas of progress in each of these domains, including data that appear to favor an effect of tDCS on neural oscillations rather than spiking, and findings that tDCS administration to the prefrontal cortex during task training may be an effective way to enhance behavioral performance. Finally, we provide suggestions for further empirical study that will elucidate the impact of tDCS on brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorders.

Indexed as

BrainCognitionHumansMajor Depressive DisorderMental DisordersNeuronsPrefrontal CortexSchizophreniaTranscranial Direct Current Stimulation

Identifiers

PMID31455860
PMCPMC6981019
OpenAlexW2970012072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.