Evidence map›Paper›PMID 31455859›Full record

ReviewMolecular psychiatry2020

The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders.

K M Lee, Z H Hawi, H C Parkington, C L Parish, P V Kumar, J M Polo, M A Bellgrove, J Tong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

K M LeeTurner Institute for Brain and Mental Health and the School of Psychological Sciences, Monash University, Melbourne, Australia.
Z H HawiTurner Institute for Brain and Mental Health and the School of Psychological Sciences, Monash University, Melbourne, Australia.
H C ParkingtonBiomedicine Discovery Institute, Monash University, Melbourne, Australia.
C L ParishFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
P V KumarTurner Institute for Brain and Mental Health and the School of Psychological Sciences, Monash University, Melbourne, Australia.
J M PoloBiomedicine Discovery Institute, Monash University, Melbourne, Australia.ORCID http://orcid.org/0000-0002-2531-778X
M A BellgroveTurner Institute for Brain and Mental Health and the School of Psychological Sciences, Monash University, Melbourne, Australia.ORCID http://orcid.org/0000-0003-0186-8349
J TongTurner Institute for Brain and Mental Health and the School of Psychological Sciences, Monash University, Melbourne, Australia. janettehstong@gmail.com.ORCID http://orcid.org/0000-0002-3269-1438
Monash University · AUAustralian Regenerative Medicine Institute · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular models of neurodevelopmental disorders provide a valuable experimental system to uncover disease mechanisms and novel therapeutic strategies. The ability of induced pluripotent stem cells (iPSCs) to generate diverse brain cell types offers great potential to model several neurodevelopmental disorders. Further patient-derived iPSCs have the unique genetic and molecular signature of the affected individuals, which allows researchers to address limitations of transgenic behavioural models, as well as generate hypothesis-driven models to study disorder-relevant phenotypes at a cellular level. In this article, we review the extant literature that has used iPSC-based modelling to understand the neuronal and glial contributions to neurodevelopmental disorders including autism spectrum disorder (ASD), Rett syndrome, bipolar disorder (BP), and schizophrenia. For instance, several molecular candidates have been shown to influence cellular phenotypes in three-dimensional iPSC-based models of ASD patients. Delays in differentiation of astrocytes and morphological changes of neurons are associated with Rett syndrome. In the case of bipolar disorders and schizophrenia, patient-derived models helped to identify cellular phenotypes associated with neuronal deficits (e.g., excitability) and mutation-specific abnormalities in oligodendrocytes (e.g., CSPG4). Further we provide a critical review of the current limitations of this field and provide methodological suggestions to enhance future modelling efforts of neurodevelopmental disorders. Future developments in experimental design and methodology of disease modelling represent an exciting new avenue relevant to neurodevelopmental disorders.

Indexed as

AstrocytesCell DifferentiationHumansInduced Pluripotent Stem CellsModels, BiologicalNeurodevelopmental DisordersNeurogliaNeuronsPhenotypePluripotent Stem Cells

Identifiers

PMID31455859
OpenAlexW2970834238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.