Evidence map›Paper›PMID 31455740›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Diverse conjugative elements silence natural transformation in

Isabelle Durieux, Christophe Ginevra, Laetitia Attaiech, Kévin Picq, Pierre-Alexandre Juan, Sophie Jarraud, Xavier Charpentier

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

  1. Utilizing natural competence to genetically manipulateApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Journal of bacteriology · 2024
    Review
  13. Article
  14. Article
  15. Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Article
  18. Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  19. Article
  20. Bacterial DNA involvement in carcinogenesis.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Isabelle DurieuxTeam "Horizontal gene transfer in bacterial pathogens," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69100 Villeurbanne, France.
Christophe GinevraTeam "Pathogenesis of Legionella," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69008 Villeurbanne, France.
Laetitia AttaiechTeam "Horizontal gene transfer in bacterial pathogens," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69100 Villeurbanne, France.
Kévin PicqTeam "Horizontal gene transfer in bacterial pathogens," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69100 Villeurbanne, France.
Pierre-Alexandre JuanTeam "Horizontal gene transfer in bacterial pathogens," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69100 Villeurbanne, France.
Sophie JarraudTeam "Pathogenesis of Legionella," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69008 Villeurbanne, France.
Xavier CharpentierTeam "Horizontal gene transfer in bacterial pathogens," Centre International de Recherche en Infectiologie, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR 5308, École Normale Supérieure de Lyon, Université de Lyon, 69100 Villeurbanne, France; xavier.charpentier@univ-lyon1.fr.ORCID 0000-0001-9039-8021
Université Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural transformation (i.e., the uptake of DNA and its stable integration in the chromosome) is a major mechanism of horizontal gene transfer in bacteria. Although the vast majority of bacterial genomes carry the genes involved in natural transformation, close relatives of naturally transformable species often appear not competent for natural transformation. In addition, unexplained extensive variations in the natural transformation phenotype have been reported in several species. Here, we addressed this phenomenon by conducting a genome-wide association study (GWAS) on a panel of isolates of the opportunistic pathogen

Indexed as

Gene Transfer, HorizontalTransformation, BacterialBacterial ProteinsDNA-Binding ProteinsGene SilencingGenome-Wide Association StudyLegionella pneumophilaMolecular ChaperonesPlasmidsRNARNA, Small UntranslatedBacterial ProteinsDNA-Binding ProteinsMolecular ChaperonesRNARNA, Small Untranslatedconjugative elementhorizontal gene transferLegionella pneumophilanatural transformationnoncoding RNA

Identifiers

PMID31455740
PMCPMC6744872
OpenAlexW2970660898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.