Evidence map›Paper›PMID 31455724›Full record

ArticleScience signaling2019

SMAC mimetics throw a molecular switch to control T

Stephanie K Dougan, Michael Dougan

Abstract readComment
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Stephanie K DouganDepartment of Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. stephanie_dougan@dfci.harvard.edu mldougan@partners.org.ORCID 0000-0002-2263-363X
Michael DouganDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. stephanie_dougan@dfci.harvard.edu mldougan@partners.org.

Funding

Systematic interrogation of the pancreatic cancer microenvironment in patient-derived specimensU01CA224146 · NCI · DANA-FARBER CANCER INST · PI HAHN, WILLIAM C. · 2017 to 2021
$3.0M
Regulation of brown fat metabolism by the immune receptor PD-L1K08DK114563 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGAN, MICHAEL LAWRENCE · 2017 to 2021
$868k
NCI NIH HHS U01 CA224146NIDDK NIH HHS K08 DK114563
6 · The paper itself

Abstract

IL-17 produced by T

Indexed as

Intracellular Signaling Peptides and ProteinsTh17 CellsApoptosisCell DifferentiationInhibitor of Apoptosis ProteinsMitochondrial ProteinsInhibitor of Apoptosis ProteinsIntracellular Signaling Peptides and ProteinsMitochondrial Proteins

Identifiers

PMID31455724
PMCPMC7525609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.