Evidence map›Paper›PMID 31455722›Full record

ArticleGenetics2019

Genetic Signatures of Drug Response Variability in

Palle Duun Rohde, Iben Ravnborg Jensen, Pernille Merete Sarup, Michael Ørsted, Ditte Demontis, Peter Sørensen, Torsten Nygaard Kristensen

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Use ofBiomedicines · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Palle Duun RohdeCenter for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, 8830 Tjele, Denmark palle.d.rohde@mbg.au.dk.ORCID 0000-0003-4347-8656
Iben Ravnborg JensenSection for Biology and Environmental Science, Department of Chemistry and Bioscience, Aalborg University, 9220, Denmark.
Pernille Merete SarupCenter for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, 8830 Tjele, Denmark.
Michael ØrstedSection for Biology and Environmental Science, Department of Chemistry and Bioscience, Aalborg University, 9220, Denmark.ORCID 0000-0001-8222-8399
Ditte DemontisThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8000 Aarhus C, Denmark.ORCID 0000-0001-9124-2766
Peter SørensenCenter for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, 8830 Tjele, Denmark.
Torsten Nygaard KristensenSection for Biology and Environmental Science, Department of Chemistry and Bioscience, Aalborg University, 9220, Denmark.ORCID 0000-0001-6204-8753
Aarhus University · DKAalborg University · DKLundbeck Foundation · DK

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Knowledge of the genetic basis underlying variation in response to environmental exposures or treatments is important in many research areas. For example, knowing the set of causal genetic variants for drug responses could revolutionize personalized medicine. We used

Indexed as

GenomicsAnimalsAttention Deficit Disorder with HyperactivityDrosophila melanogasterEpistasis, GeneticFemaleGene Expression RegulationGenetic Association StudiesGenetic VariationGenome, InsectHumansLocomotionMaleMethylphenidateTranscriptomeMethylphenidateADHDcross-generational effectsDrosophila Genetic Reference Panellocomotor activityRitalin

Identifiers

PMID31455722
PMCPMC6781897
OpenAlexW2970945967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.