Evidence map›Paper›PMID 31455657›Full record

ArticlemBio2019

Comparative Genomics of Antibiotic-Resistant Uropathogens Implicates Three Routes for Recurrence of Urinary Tract Infections.

Robert Thänert, Kimberly A Reske, Tiffany Hink, Meghan A Wallace, Bin Wang, Drew J Schwartz, Sondra Seiler, Candice Cass, C A Burnham, Erik R Dubberke and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Safety and immunogenicity of an adjuvantedHuman vaccines & immunotherapeutics · 2021
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Bacteriophage-mediated reduction of uropathogenicbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Robert ThänertThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kimberly A ReskeDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Tiffany HinkDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Meghan A WallaceDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Bin WangThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Drew J SchwartzThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sondra SeilerDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Candice CassDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
C A BurnhamDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-1137-840X
Erik R DubberkeDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.
Jennie H KwonDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.
Gautam DantasThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA edubberk@wustl.edu j.kwon@wustl.edu dantas@wustl.edu.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0M
PHYLOGENOMIC, TRANSCRIPTOMIC, VIROMIC, AND IMMUNOPROTEOMIC DETERMINANTS OF NECROTIZING ENTEROCOLITISR01HD092414 · NICHD · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, TARR, PHILLIP I · 2017 to 2021
$3.0M
STRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESR01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2016 to 2019
$2.7M
Longitudinal Analysis of the Fecal Microbiome and Resistome of Patients with Multidrug-Resistant Urinary Tract Infections and Predictors of RecurrenceK23AI137321 · NIAID · WASHINGTON UNIVERSITY · PI KWON, JENNIE H · 2019 to 2022
$675k
NCATS NIH HHS KL2 TR002346NCATS NIH HHS UL1 TR002345NCEZID CDC HHS U54 CK000482NCEZID CDC HHS U54 CK000609NIAID NIH HHS K23 AI137321NIAID NIH HHS R01 AI123394NICHD NIH HHS R01 HD092414
6 · The paper itself

Abstract

The rise of antimicrobial resistance in uropathogens has complicated the management of urinary tract infections (UTIs), particularly in patients who are afflicted by recurrent episodes of UTIs. Antimicrobial-resistant (AR) uropathogens persistently colonizing individuals at asymptomatic time points have been implicated in the pathophysiology of UTIs. The dynamics of uropathogen persistence following the resolution of symptomatic disease are, however, mostly unclear. To further our understanding, we determined longitudinal AR uropathogen carriage and clonal persistence of uropathogenic

Indexed as

GenomicsAdultAgedAged, 80 and overAnti-Bacterial AgentsCohort StudiesEscherichia coliHumansKlebsiella pneumoniaeLongitudinal StudiesMiddle AgedPhylogenyProteus mirabilisRecurrenceUrinary Tract InfectionsAnti-Bacterial Agentsantibiotic resistanceclonal trackingcomparative genomicsrecurrenceurinary tract infection

Identifiers

PMID31455657
PMCPMC6712402
OpenAlexW2970854737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.