Evidence map›Paper›PMID 31455648›Full record

ReviewmBio2019

Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility.

Volkan K Köseoğlu, Hervé Agaisse

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Moonlighting in Rickettsiales: Expanding Virulence Landscape.Tropical medicine and infectious disease · 2022
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Volkan K KöseoğluDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Hervé AgaisseDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA hfa5y@virginia.edu.
University of Virginia · US

Funding

Mechanisms of intracellular pathogen disseminationR01AI073904 · NIAID · YALE UNIVERSITY · PI AGAISSE, HERVE F · 2007 to 2022
$5.5M
NIAID NIH HHS R01 AI073904
6 · The paper itself

Abstract

Various bacterial pathogens display an intracellular lifestyle and spread from cell to cell through actin-based motility (ABM). ABM requires actin polymerization at the bacterial pole and is mediated by the expression of bacterial factors that hijack the host cell actin nucleation machinery or exhibit intrinsic actin nucleation properties. It is increasingly recognized that bacterial ABM factors, in addition to having a crucial task during the intracellular phase of infection, display "moonlighting" adhesin functions, such as bacterial aggregation, biofilm formation, and host cell adhesion/invasion. Here, we review our current knowledge of ABM factors and their additional functions, and we propose that intracellular ABM functions have evolved from ancestral, extracellular adhesin functions.

Indexed as

Bacterial Physiological PhenomenaActinsBacteriaBacterial AdhesionBacterial ProteinsBiofilmsHost-Pathogen InteractionsHumansListeriaShigellaActinsBacterial ProteinsActAactin-based motilityadhesionaggregationbiofilmextracellular pathogenIcsAintracellular pathogeninvasionListeriamoonlightingShigella

Identifiers

PMID31455648
PMCPMC6712393
OpenAlexW2971175123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.