Evidence map›Paper›PMID 31455640›Full record

ArticlemSystems2019

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.

Benjamin C Creekmore, Josh H Gray, William G Walton, Kristen A Biernat, Michael S Little, Yongmei Xu, Jian Liu, Raad Z Gharaibeh, Matthew R Redinbo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
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  9. Integrating the gut microbiome and pharmacology.Science translational medicine · 2024
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Benjamin C CreekmoreDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Josh H GrayDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-3388-5867
William G WaltonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kristen A BiernatDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael S LittleDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Yongmei XuChemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jian LiuChemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Raad Z GharaibehDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Matthew R RedinboDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA redinbo@unc.edu.ORCID https://orcid.org/0000-0003-0814-5346
University of North Carolina at Chapel Hill · USUniversity of Florida · US

Funding

Improving CPT-11 Efficacy Using Structural BiologyR01CA098468 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2003 to 2018
$3.9M
Microbiome-Targeted Probes to Eliminate Chemotherapy-Induced GI ToxicityR01CA207416 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REDINBO, MATTHEW R · 2016 to 2018
$1.7M
NCI NIH HHS R01 CA098468NCI NIH HHS R01 CA207416
6 · The paper itself

Abstract

Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human Microbiome Project stool sample database and revealed 279 unique GUS enzymes organized into six categories based on active-site structural features. Because mice represent a model biomedical research organism, here we provide an analogous catalog of mouse intestinal microbial GUS proteins-a mouse gut GUSome. Using metagenome analysis guided by protein structure, we examined 2.5 million unique proteins from a comprehensive mouse gut metagenome created from several mouse strains, providers, housing conditions, and diets. We identified 444 unique GUS proteins and organized them into six categories based on active-site features, similarly to the human GUSome analysis. GUS enzymes were encoded by the major gut microbial phyla, including

Indexed as

beta-glucuronidasegut microbiomemouse metagenomicsprotein structure-function

Identifiers

PMID31455640
PMCPMC6712278
OpenAlexW2970482505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.