ArticlemSystems2019
Molecular Dating of the Emergence of Anaerobic Rumen Fungi and the Impact of Laterally Acquired Genes.
Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Single-Thallus Genomics of Ejectosporus trisporus, an Unculturable Stonefly Gut Fungal Symbiont.Environmental microbiology · 2026Article
- Gene duplication, horizontal gene transfer, and trait trade-offs drive evolution of postfire resource acquisition in pyrophilous fungi.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Full ribosomal operon sequencing of anaerobic gut fungi (phylumIMA fungus · 2026Article
- Effects of cotton straw added to total mixed pelleted feed on the composition of rumen microbiota in breeding ewes.Frontiers in microbiology · 2025Article
- Regulation of Milk Fat Synthesis: Key Genes and Microbial Functions.Microorganisms · 2024Review
- Structural, Biochemical, and Phylogenetic Analysis of Bacterial and Fungal Carbohydrate Esterase Family 15 Glucuronoyl Esterases in the Rumen.The protein journal · 2024Article
- Anaerobic fungi in the tortoise alimentary tract illuminate early stages of host-fungal symbiosis and Neocallimastigomycota evolution.Nature communications · 2024Article
- Herptile gut microbiomes: a natural system to study multi-kingdom interactions between filamentous fungi and bacteria.mSphere · 2024Article
- Forage lignocellulose is an important factor in driving the seasonal dynamics of rumen anaerobic fungi in grazing yak and cattle.Microbiology spectrum · 2023Article
- Identification and expression of small multidrug resistance transporters in early-branching anaerobic fungi.Protein science : a publication of the Protein Society · 2023Article
- Patterns and determinants of the global herbivorous mycobiome.Nature communications · 2023Article
- Taxonomy, phylogeny and identification ofStudies in mycology · 2022Article
- Wild herbivorous mammals (genusSymbiosis (Philadelphia, Pa.) · 2022Article
- Cryogenian Origin and Subsequent Diversification of the Plant Cell-Wall Enzyme XTH Family.Plant & cell physiology · 2021Article
- Article
- New Method for Identifying Fungal Kingdom Enzyme Hotspots from Genome Sequences.Journal of fungi (Basel, Switzerland) · 2021Article
- Article
- Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont,G3 (Bethesda, Md.) · 2020Article
- Anaerobic Fungi: Past, Present, and Future.Frontiers in microbiology · 2020Review
- Fungal evolution: diversity, taxonomy and phylogeny of the Fungi.Biological reviews of the Cambridge Philosophical Society · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The anaerobic gut fungi (AGF), or Neocallimastigomycota, inhabit the rumen and alimentary tract of herbivorous mammals, where they play important roles in the degradation of plant fiber. Comparative genomic and phylogenomic analyses of the AGF have long been hampered by their fastidious growth condition, as well as their large (up to 200 Mb) and AT-biased (78 to 84%) genomes. We sequenced 21 AGF transcriptomes and combined them with 5 available AGF genome sequences to explore their evolutionary relationships, time their divergence, and characterize gene gain/loss patterns associated with their evolution. We estimate that the most recent common ancestor of the AGF diverged 66 (±10) million years ago, a time frame that coincides with the evolution of grasses (Poaceae), as well as the mammalian transition from insectivory to herbivory. The concordance of independent estimations suggests that AGF have been important in shaping the success of mammalian herbivory transition by improving the efficiency of energy acquisition from recalcitrant plant materials. Comparative genomics identified multiple lineage-specific genes in the AGF, two of which were acquired from rumen gut bacteria and animal hosts via horizontal gene transfer (HGT). A third AGF domain, plant-like polysaccharide lyase, represents a novel gene in fungi that potentially aids AGF to degrade pectin. Analysis of genomic and transcriptomic sequences confirmed both the presence and expression of these lineage-specific genes in nearly all AGF clades. These genetic elements may contribute to the exceptional abilities of AGF to degrade plant biomass and enable metabolism of the rumen microbes and animal hosts.
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