Evidence map›Paper›PMID 31455609›Full record

ArticleRNA (New York, N.Y.)2019

Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P.

Agnes Karasik, Carol A Fierke, Markos Koutmos

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Late onset of type 2 diabetes is associated with mitochondrial tRNAJournal of clinical laboratory analysis · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Agnes KarasikDepartment of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.
Carol A FierkeDepartment of Chemistry, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Markos KoutmosDepartment of Chemistry, Program in Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
University of Michigan · USUniformed Services University of the Health Sciences · US

Funding

ENZYMOLOGY OF RNA PROCESSING ENZYMESR01GM055387 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FIERKE, CAROL A · 1997 to 2014
$4.3M
Structural and functional basis for protein-based eukaryotic RNA processingR01GM117141 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Markos Koutmos · 2016 to 2026
$2.5M
NIGMS NIH HHS R01 GM055387NIGMS NIH HHS R01 GM117141
6 · The paper itself

Abstract

Human mitochondrial ribonuclease P (mtRNase P) is an essential three-protein complex that catalyzes the 5' end maturation of mitochondrial precursor tRNAs (pre-tRNAs). Mitochondrial RNase P Protein 3 (MRPP3), a protein-only RNase P (PRORP), is the nuclease component of the mtRNase P complex and requires a two-protein

Indexed as

RNA Processing, Post-TranscriptionalHumansMethylationMitochondriaProtein BindingRibonuclease PRNA, TransferSubstrate SpecificityRibonuclease PRNA, TransfermitochondriaMRPPpre-tRNA methylationPRORPRNase P

Identifiers

PMID31455609
PMCPMC6859853
OpenAlexW2970819195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.