ArticleBrazilian journal of otorhinolaryngology
Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 39 citations in OpenAlex.
- Epithelial Markers in Sinonasal Inverted Papilloma with Malignant Transformation: A Scoping Review and Proposal for an Integrative Model of Malignant Risk Stratification.Diagnostics (Basel, Switzerland) · 2026Review
- Sinonasal Inverted Papillomas: Predictors of Recurrence and Malignant Transformation.Life (Basel, Switzerland) · 2026Article
- Clinical and Epidemiological Profile of Patients with Sinonasal Papilloma in a University Hospital.International archives of otorhinolaryngology · 2026Article
- Human Papillomavirus: Possible Mechanisms of Damage in Sinonasal Inverted Papilloma.International journal of molecular sciences · 2025Review
- The characteristics of sinonasal inverted papilloma and recurrence factors: An analysis of 207 cases.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Expression and clinical significance of the p53/SAT1/ALOX15 ferroptosis-associated proteins in sinonasal inverted papilloma.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Tissue microRNA dynamics in sinonasal inverted papilloma: implications for pathology and therapy.Tissue barriers · 2025Review
- Article
- HPV11 targeting KDM4A regulates the polarization of macrophage MCell communication and signaling : CCS · 2024Article
- The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Unique clinical and prognostic behavior of patients diagnosed with combined exophytic and inverted papilloma histologic subtype.Laryngoscope investigative otolaryngology · 2024Article
- An in vitro model and the underlying pathways of sinonasal inverted papilloma development.Scientific reports · 2023Article
- Blood-stained tears-a red flag for malignancy?Eye (London, England) · 2023Article
- Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- A Rare Case of Cervical Squamous Cell Carcinoma Concurrent with Sinonasal Inverted Papilloma: A Case Report.International journal of women's health · 2022Article
- Dynamic Incision under Nasal Endoscope and Low-Temperature Plasma Radiofrequency Ablation for Nasal Inverted Papilloma: An Analysis of Differences in Efficacy and the Destructive Effect on Immune Function.Computational and mathematical methods in medicine · 2022Article
- Bilateral Sinonasal Inverted Papilloma: Report of an Uncommon Case Involving Sinuses of the Face and Orbital Cavity.The American journal of case reports · 2021Article
- Patterns of Recurrence and Malignant Transformation in Sinonasal Papilloma: Implications for Long-term Follow-up.In vivo (Athens, Greece)Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough sinonasal inverted papillomas are benign lesions, they are locally aggressive and have a potential malignant transformation ranging from 5% to 15%, with a high recurrence rate.
objectiveThe aim of this article is to describe the rate of recurrence and malignant transformation in patients with a diagnosis of inverted papilloma who underwent surgery in a tertiary hospital in São Paulo.
methodsWe performed a retrospective analysis of patients diagnosed with sinonasal papilloma who had undergone surgery in a tertiary hospital in São Paulo, between August 1998 and August 2017. A patient chart review was conducted to assess data of patients' demographics, tumors characteristics, follow-up appointments, recurrence and malignancy. Inverted papillomas were analyzed and classified under the Krouse staging system.
resultsA total of 69 surgeries were performed in patients with diagnosis of sinonasal papilloma. Inverted papilloma was the most prevalent subtype (49 cases ‒ 80.33%), followed by exophytic papilloma (6 cases ‒ 9.84%) and by oncocytic papilloma (6 cases - 9.84%). The recurrence rate was 34.09% for inverted papilloma (15/44) and the mean time of recurrence was 24.6 months. Malignant transformation occurred in 6 patients (13.64%). Three of these patients presented carcinoma in the first surgery and three patients developed carcinoma during the follow-up.
conclusionThe high recurrence rate and malignancy potential allow us to consider inverted papillomas as aggressive tumors. In a tertiary hospital in São Paulo the recurrence rate the mean time to recurrence is 24.6 months. The recurrence after 10 years implies was 34.09% and the need for long-term follow up. It is possible that the high recurrence rate and the high malignant transformation rate we found are due to the large number of tumors discovered at an advanced stage (most of them staged T3 and T4), secondary to poor access to health system, in developing countries.
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