ArticleItalian journal of pediatrics2019
Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice.
Article in Italian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Inflammatory Markers in the Blood of Spastic Cerebral Palsy Children: A Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Kynurenine Pathway in Respiratory Diseases.International journal of tryptophan research : IJTR · 2024Review
- The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma.FEMS microbes · 2024Article
- A Metabolites Merging Strategy (MMS): Harmonization to Enable Studies' Intercomparison.Metabolites · 2023Article
- The Role of Diet and Nutrition in Allergic Diseases.Nutrients · 2023Review
- Association of Metabolites, Nutrients, and Toxins in Maternal and Cord Serum with Asthma, IgE, SPT, FeNO, and Lung Function in Offspring.Metabolites · 2023Article
- The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma.bioRxiv : the preprint server for biology · 2023Article
- Metabolite Comparison between Spleen-Deficiency and Healthy Children.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.Cell reports. Medicine · 2022Article
- Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment.Metabolites · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.