ArticleBMC geriatrics2019
Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study.
Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Frailty risk prediction models in maintenance hemodialysis patients: a systematic review and meta-analysis of model performance and methodological quality.Renal failure · 2025Pooled it
- Prevalence and risk factors of sarcopenia in patients with stroke: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Sarcopenia and blood albumin: A systematic review with meta-analysisBiomedica : revista del Instituto Nacional de Salud · 2021Pooled it
- Respiratory muscle training with electronic devices in the postoperative period of hepatectomy: A randomized study.World journal of hepatology · 2023Trial
- Low muscle mass, obesity, and cause-specific mortality in cancer patients: a nationwide cohort study.Cancer causes & control : CCC · 2026Article
- The association between Helicobacter pylori and osteoporosis: the mediating effect of inflammation.Gut pathogens · 2026Article
- Muscle mass and function in patients with type 2 diabetes mellitus: a characteristic analysis based on sex, age, and BMI.Frontiers in endocrinology · 2026Article
- Integrating chronic inflammation and hypoxia: the potential role of HIF-1α in tumor behavior and therapy response in high-grade serous ovarian cancer.Frontiers in immunology · 2026Article
- Correlation of neutrophil- and high-density lipoprotein cholesterol-related inflammatory markers with sarcopenia: Insights from a cross-sectional study.The Journal of international medical research · 2026Article
- Association of red cell distribution width-to-albumin ratio with mortality in adults with low muscle mass: A retrospective cohort study.The Journal of international medical research · 2026Article
- Association between dietary inflammatory index and sarcopenia development in Polish population.Scientific reports · 2025Article
- Mediation effects of age, intramuscular adipose tissue index and serum albumin on survival status in initial dialysis patients.Renal failure · 2025Article
- Predictive value of temporal muscle thickness for prognosis in newly diagnosed IDH wild-type glioblastoma patients: evaluated for a Chinese population.European radiology · 2025Article
- Risk Factors and Predictive Models for Sarcopenia in Older Adults.Aging medicine (Milton (N.S.W)) · 2025Article
- Cross-Sectional Associations between Clinical Biochemistry and Nutritional Biomarkers and Sarcopenic Indices of Skeletal Muscle in the Baltimore Longitudinal Study of Aging.The Journal of nutrition · 2025Article
- Sarcopenia in Rheumatic Diseases: A Hidden Issue of Concern.Diseases (Basel, Switzerland) · 2025Review
- Radiological extent predicts prognosis and relapse after acute exacerbation of interstitial lung disease in patients with rheumatoid arthritis: KEIO-RA-cohort.Rheumatology international · 2025Article
- The association of HALP score with low muscle mass in older adults.Frontiers in nutrition · 2025Article
- Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory parameters.Frontiers in medicine · 2025Article
- Modified geriatric nutritional risk index: a high-sensitivity marker with L-shaped association for sarcopenia in hospitalized older adults.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients.
methodsData from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia.
resultsA total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95% CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95% CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95% CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95% CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95% CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia.
conclusionsIn geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.
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