Evidence map›Paper›PMID 31454963›Full record

ArticlePharmaceuticals (Basel, Switzerland)2019

Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell.

Paola Poma, Manuela Labbozzetta, James A McCubrey, Aro Vonjy Ramarosandratana, Maurizio Sajeva, Pietro Zito, Monica Notarbartolo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Biological Activities and Chemical Profiles ofPlants (Basel, Switzerland) · 2023
    Article
  2. Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia.International journal of molecular sciences · 2023
    Review
  3. Potential ofMolecules (Basel, Switzerland) · 2022
    Review
  4. Antitumor Effect ofMolecules (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Review
  7. In Vitro Modulation of P-Glycoprotein Activity byPharmaceuticals (Basel, Switzerland) · 2021
    Article
  8. Review
  9. Essential Oil fromMolecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Paola PomaDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Manuela LabbozzettaDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Aro Vonjy RamarosandratanaDepartment of Plant Biology and Ecology, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.ORCID 0000-0002-1828-7834
Maurizio SajevaDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy. maurizio.sajeva@unipa.it.ORCID 0000-0003-4731-7112
Pietro ZitoDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-6188-5434
Monica NotarbartoloDepartment of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy. monica.notarbartolo@unipa.it.
University of Palermo · ITEast Carolina University · USUniversity of Antananarivo · MG

Funding

This work was partially financed by PJ_AUTF_160829_D15 to Monica Notarbartolo. PJ_AUTF_160829_D15
6 · The paper itself

Abstract

Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of

Indexed as

acute myeloid leukemia cellCyphostemma juttaeessential oilKalanchoe beharensismultidrug resistanceNF-κB

Identifiers

PMID31454963
PMCPMC6789815
OpenAlexW2969992744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.