Evidence map›Paper›PMID 31454910›Full record

ArticleInternational journal of molecular sciences2019

Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the

Perry E Davis, Emily C Wilkinson, Robert M Dores

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Structure and Function of Membrane Proteins.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Perry E DavisDepartment of Biological Sciences, University of Denver, Denver, CO 80210, USA.
Emily C WilkinsonDepartment of Biological Sciences, University of Denver, Denver, CO 80210, USA.
Robert M DoresDepartment of Biological Sciences, University of Denver, Denver, CO 80210, USA. robert.dores@du.edu.
University of Denver · US

Funding

Long Premed Research Fund 148247
6 · The paper itself

Abstract

The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact with corresponding contact sites on MC2R. Earlier studies have localized the common HFRW binding site of all melanocortin receptors to residues in TM2, TM3, and TM6 that are located close to the extracellular space. The current study has identified residues in

Indexed as

Adrenocorticotropic HormoneAmino Acid SequenceAnimalsCell MembraneCHO CellsCricetulusHumansMutationReceptor, Melanocortin, Type 2XenopusAdrenocorticotropic HormoneReceptor, Melanocortin, Type 2activationmelanocortin-2 receptorXenopus tropicalis

Identifiers

PMID31454910
PMCPMC6747542
OpenAlexW2969646481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.