ArticleInternational journal for numerical methods in biomedical engineering2019
Analysis of a coupled fluid-structure interaction model of the left atrium and mitral valve.
Article in International journal for numerical methods in biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Toward precision in simulation of paediatric mitral valve repair using patient-specific fluid-structure interaction modelling.European heart journal. Imaging methods and practice · 2026Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.PLoS computational biology · 2025Article
- Image-based, whole-system hemodynamic modeling of mitral regurgitation and its impact on the right ventricular function.Frontiers in cardiovascular medicine · 2025Article
- Multiphysics simulations reveal haemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics.The Journal of physiology · 2024Article
- Multi-Modal in Vitro Experiments Mimicking the Flow Through a Mitral Heart Valve Phantom.Cardiovascular engineering and technology · 2024Article
- The role of the pulmonary veins on left atrial flow patterns and thrombus formation.Scientific reports · 2024Article
- Feasibility of concomitant exclusion of left atrial appendage during novel transapical off-pump beating heart mitral valve repair.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Article
- The role of computational methods in cardiovascular medicine: a narrative review.Translational pediatrics · 2024Review
- Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.Biomechanics and modeling in mechanobiology · 2023Article
- Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways.Frontiers in physics · 2023Article
- Pulmonary vein flow split effects in patient-specific simulations of left atrial flow.Computers in biology and medicine · 2023Article
- An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse.Cardiovascular engineering and technology · 2023Article
- Influence of Inlet Boundary Conditions on the Prediction of Flow Field and Hemolysis in Blood Pumps Using Large-Eddy Simulation.Bioengineering (Basel, Switzerland) · 2023Article
- Machine Learning and the Conundrum of Stroke Risk Prediction.Arrhythmia & electrophysiology review · 2023Review
- Domain expert evaluation of advanced visual computing solutions and 3D printing for the planning of the left atrial appendage occluder interventions.International journal of bioprinting · 2023Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- Stroke risk evaluation for patients with atrial fibrillation: Insights from left atrial appendage.Frontiers in cardiovascular medicine · 2022Review
- Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model.Biomechanics and modeling in mechanobiology · 2021Article
- A poroelastic immersed finite element framework for modelling cardiac perfusion and fluid-structure interaction.International journal for numerical methods in biomedical engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We present a coupled left atrium-mitral valve model based on computed tomography scans with fibre-reinforced hyperelastic materials. Fluid-structure interaction is realised by using an immersed boundary-finite element framework. Effects of pathological conditions, eg, mitral valve regurgitation and atrial fibrillation, and geometric and structural variations, namely, uniform vs non-uniform atrial wall thickness and rule-based vs atlas-based fibre architectures, on the system are investigated. We show that in the case of atrial fibrillation, pulmonary venous flow reversal at late diastole disappears, and the filling waves at the left atrial appendage orifice during systole have reduced magnitude. In the case of mitral regurgitation, a higher atrial pressure and disturbed flows are seen, especially during systole, when a large regurgitant jet can be found with the suppressed pulmonary venous flow. We also show that both the rule-based and atlas-based fibre defining methods lead to similar flow fields and atrial wall deformations. However, the changes in wall thickness from non-uniform to uniform tend to underestimate the atrial deformation. Using a uniform but thickened wall also lowers the overall strain level. The flow velocity within the left atrial appendage, which is important in terms of appendage thrombosis, increases with the thickness of the left atrial wall. Energy analysis shows that the kinetic and dissipation energies of the flow within the left atrium are altered differently by atrial fibrillation and mitral valve regurgitation, providing a useful indication of the atrial performance in pathological situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.