ArticleAging2019
Low triiodothyronine syndrome is associated with hemorrhagic transformation in patients with acute ischaemic stroke.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Association Between Free Triiodothyronine to Free Thyroxine Ratio and Hemorrhagic Transformation After Intravenous Thrombolysis in Acute Ischemic Stroke Patients.Brain and behavior · 2025Observational
- Role of thyroid function in non-basal ganglia intracerebral hemorrhage prognosis.Journal of endocrinological investigation · 2025Article
- What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study.BMC geriatrics · 2024Article
- Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- The differences of fibrinogen levels in various types of hemorrhagic transformations.Frontiers in neurology · 2024Article
- Investigating the Predictive Value of Thyroid Hormone Levels for Stroke Prognosis.Neurology international · 2023Review
- Low T3 syndrome as a predictor of poor outcomes in patients with follicular lymphoma.Annals of hematology · 2023Article
- Thyroid hormones and platelet activation in COVID-19 patients.Journal of endocrinological investigation · 2023Article
- Thyroid stimulating hormone correlates with triglyceride levels but is not associated with the severity of acute ischemic stroke in patients with euthyroidism: a cross-sectional study.Annals of translational medicine · 2023Article
- Nomogram to predict hemorrhagic transformation for acute ischemic stroke in Western China: a retrospective analysis.BMC neurology · 2022Article
- Free Triiodothyronine Is Associated with Poor Outcomes after Acute Ischemic Stroke.International journal of clinical practice · 2022Article
- Hemostasis functions are associated with hemorrhagic transformation in non-atrial fibrillation patients: a case-control study.BMC neurology · 2021Article
- Low Free Triiodothyronine as a Predictor of Poor Prognosis in Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries.Frontiers in endocrinology · 2021Observational
- Identification of Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke After Endovascular Therapy Using the Decision Tree Model.Clinical interventions in aging · 2020Article
- Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke.Frontiers in neurology · 2020Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemorrhagic transformation (HT) is a severe complication occurring in acute ischemic stroke (AIS) patients. We explored the association between low triiodothyronine (T3) syndrome and HT in AIS patients. A total of 208 consecutive participants with HT and 208 age- and sex-matched stroke patients without HT were enrolled in this study. HT was diagnosed by follow-up imaging assessment, and was radiologically classified as hemorrhagic infarction (HI) type 1 or 2 or parenchymal hematoma (PH) type 1 or 2. HT was also classified into asymptomatic or symptomatic. The incidence of low T3 syndrome was significantly higher among patients who developed HT than among those without HT. Moreover, the more severe the HT, the lower the detected T3 levels. Multivariate-adjusted binary logistic regression showed that low T3 syndrome was an independent risk factor for HT and symptomatic HT in AIS patients. Low T3 syndrome was also significantly associated with a higher risk of PH, but not with the risk of HI. Thus, low T3 syndrome was independently associated with the risk of HT, symptomatic HT, and severe HT (PH) in AIS patients, which suggests monitoring T3 could be a useful means of preventing HT in patients with ischemic stroke.
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