Evidence map›Paper›PMID 31454263›Full record

Trial reportAmerican journal of respiratory and critical care medicine2019

Balanced Crystalloids versus Saline in Sepsis. A Secondary Analysis of the SMART Clinical Trial.

Ryan M Brown, Li Wang, Taylor D Coston, Nathan I Krishnan, Jonathan D Casey, Jonathan P Wanderer, Jesse M Ehrenfeld, Daniel W Byrne, Joanna L Stollings, Edward D Siew and 4 more

Open access · greenAbstract readComparative StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 9 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 9 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
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  4. Guideline
  5. Guideline
  6. Pooled it
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  10. Trial
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  15. Article
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Ryan M BrownDivision of Allergy, Pulmonary, and Critical Care Medicine.ORCID 0000-0002-8778-026X
Li WangDepartment of Biostatistics.
Taylor D CostonDepartment of Medicine.
Nathan I KrishnanDepartment of Medicine.
Jonathan D CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine.
Jonathan P WandererDepartment of Anesthesiology.
Jesse M EhrenfeldDepartment of Anesthesiology.
Daniel W ByrneDepartment of Biostatistics.
Joanna L StollingsDepartment of Pharmaceutical Services.
Edward D SiewVanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Injury Research, Division of Nephrology and Hypertension, and.
Gordon R BernardDivision of Allergy, Pulmonary, and Critical Care Medicine.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine.
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine.
Pulmonary and Allergy Associates · USCancer Research And Biostatistics · USGovernment of Western Australia Department of Health · AUHypertension Institute · USVanderbilt University Medical Center · USWest Pharmaceutical Services (United Kingdom) · GB

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
The Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9M
Oxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854k
Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisR34HL105869 · NHLBI · VANDERBILT UNIVERSITY · PI RICE, TODD W · 2012 to 2014
$686k
Salivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in AdultsK23GM110469 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SELF, WESLEY H · 2015 to 2018
$683k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL143053NHLBI NIH HHS R34 HL105869NHLBI NIH HHS T32 HL087738NIGMS NIH HHS K23 GM110469
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Critical CareAdultAgedCross-Over StudiesCrystalloid SolutionsFemaleHospitalizationHospital MortalityHumansMaleMiddle AgedSepsisTreatment OutcomeCrystalloid Solutionsbalanced crystalloidslactated Ringer’ssalinesepsisseptic shock

Identifiers

PMID31454263
PMCPMC6909845
OpenAlexW2970682829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.