ArticleChemical reviews2019
Reactivity and Synthetic Applications of Multicomponent Petasis Reactions.
Article in Chemical reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Secondary-Amine Relay Enables Lysine-Directed Multicomponent Functionalization of Peptides.JACS Au · 2026Article
- Dibenzo[International journal of molecular sciences · 2026Article
- Remapping the Synthetic Landscape of α-Tertiary Alkylamines via Dual-Functional Catechol.Angewandte Chemie (International ed. in English) · 2026Article
- Substituent-rebound skeletal editing for precise boron-to-carbon single-atom swapping.Nature communications · 2026Article
- Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.The Journal of organic chemistry · 2026Article
- Decarboxylative carbonyl alkylative amination: A general and practical strategy for aliphatic amine synthesis.Science advances · 2026Article
- Aminal-Linked Porous Piperazine Covalent Organic Polymers for Gold Sequestration from E-Waste with Exceptional Performance Metrics.ACS applied materials & interfaces · 2026Article
- Water-Mediated Arylation of an Imine Intermediate: A Catalyst- and Promoter-Free Three-Component Coupling in a Mortar Reactor.ACS omega · 2026Article
- Copper-Catalyzed Petasis-Type Reaction Enables Efficient Synthesis of C1-Substituted Tetrahydro-β-carbolines.Organic letters · 2026Article
- Palladium immobilized on CdFeDiscover nano · 2026Article
- Pyrazolylpyrimidinamines Decorated via Petasis Reaction as Small-Molecule Activators of the RNA-Degrading Ribonuclease IRE1α.ACS bio & med chem Au · 2026Article
- Sodium alginate-derived hydrophilic Gel@CuO microspheres: a green nanocatalyst for diverse Petasis transformations with antibacterial activity.RSC advances · 2026Article
- Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent.Nature communications · 2026Article
- Strategic 1,n-migration of boronate complexes: a novel platform for remote C-C bond construction.Molecular diversity · 2026Review
- Lactam enables remote boronate rearrangements to C═N bonds.Communications chemistry · 2026Article
- BXChemistry, an Asian journal · 2026Review
- One-Step Assembly of α-Aryl-Substituted DOTAs as Superior and Universal Platforms for Multifunctional Theranostics.Angewandte Chemie (International ed. in English) · 2025Article
- Hexafluoroisopropanol-Mediated Cascade Cyclization for Construction of α‑Amino-γ-spirolactones.JACS Au · 2025Article
- Electron donor-acceptor complex offers a diverse approach for carbonyl alkylative amination.Chemical science · 2025Article
- Regioselective Electrochemical Borylation of Oxygenated Allylic Electrophiles: Method Development and Synthetic Applications.ACS central science · 2025Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Petasis boron-Mannich reaction, simply referred to as the Petasis reaction, is a powerful multicomponent coupling reaction of a boronic acid, an amine, and a carbonyl derivative. Highly functionalized amines with multiple stereogenic centers can be efficiently accessed via the Petasis reaction with high levels of both diastereoselectivity and enantioselectivity. By drawing attention to examples reported in the past 8 years, this Review demonstrates the breadth of the reactivity and synthetic applications of Petasis reactions in several frontiers: the expansion of the substrate scope in the classic three-component process; nonclassic Petasis reactions with additional components; Petasis-type reactions with noncanonical substrates, mechanism, and products; new asymmetric versions assisted by chiral catalysts; combinations with a secondary or tertiary transformation in a cascade- or sequence-specific manner to access structurally complex, natural-product-like heterocycles; and the synthesis of polyhydroxy alkaloids and biologically interesting molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.