Evidence map›Paper›PMID 31454186›Full record

ArticleCancer medicine2019

Differences in gene expression between high-grade dysplasia and invasive HPV

Linnea Haeggblom, Andreas Ährlund-Richter, Leila Mirzaie, Pedro Farrajota Neves da Silva, Ramona G Ursu, Torbjörn Ramqvist, Anders Näsman

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. The clinical significance of receiving a kidney allograft from deceased donor with chronic histologic changes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Linnea HaeggblomDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Andreas Ährlund-RichterDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Leila MirzaieDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Pedro Farrajota Neves da SilvaDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Ramona G UrsuDepartment of Microbiology, University of Medicine and Pharmacy Grigore T. Popa Iasi, Iasi, Romania.
Torbjörn RamqvistDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-3891-496X
Anders NäsmanDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-4602-4297
Karolinska Institutet · SEKarolinska University Hospital · SEGrigore T. Popa University of Medicine and Pharmacy · RO

Funding

Åke Wibergs StiftelseCancer och AllergifondenEva och Oscar Ahréns stiftelseKarolinska InstitutetMagnus Bergvalls StiftelseStiftelsen Clas Groschinskys MinnesfondStiftelsen Sigurd och Elsa Goljes MinneStiftelsen TornspiranStockholm County CouncilSvenska läkaresällskapetSvenska Sällskapet för Medicinsk ForskningTore Nilsons Stiftelse för Medicinsk ForskningUniversity of Medicine and Pharmacy Grigore T Popa Iasi
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) is a causative agent for tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC), as well as for cervical cancer. Premalignant stages in cervical cancer have been studied extensively, while little is known about premalignant stages in TSCC/BOTSCC and the role of HPV. Here we analyzed differences in gene and protein expression between high-grade dysplasia and invasive cancer in both HPV-positive (HPV

methodsHigh-grade dysplasia and invasive carcinoma were laser microdissected from HPV

resultsForty genes in the HPV

conclusionsThis is to our knowledge the first study disclosing differences and similarities in gene expression between dysplastic and invasive HPV

Indexed as

Disease SusceptibilityGene Expression Regulation, NeoplasticPapillomaviridaeFemaleGene Expression ProfilingHumansHyperplasiaImmunohistochemistryMaleNeoplasm GradingPapillomavirus InfectionsTongue Neoplasmsbase of tongue cancercancer in situcancer progressionhigh-grade dysplasiahuman papillomavirusinvasive carcinomaoropharyngeal cancerpremalignant stagestonsillar cancer

Identifiers

PMID31454186
PMCPMC6797576
OpenAlexW2970569271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.