Evidence map›Paper›PMID 31454110›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2020

More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.

Robbin Schnieders, Sara Keyhani, Harald Schwalbe, Boris Fürtig

Open access · hybridAbstract readReview
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Application of NMR to Large RNAs.Journal of molecular biology · 2025
    Review
  2. Article
  3. Selective [9-Chembiochem : a European journal of chemical biology · 2025
    Article
  4. Article
  5. Review
  6. Fragment-Based Approaches to Identify RNA Binders.Journal of medicinal chemistry · 2023
    Review
  7. Review
  8. Review
  9. Synthesis of [7-Monatshefte fur chemie · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robbin SchniedersInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.
Sara KeyhaniInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.
Harald SchwalbeInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-5693-7909
Boris FürtigInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-6443-7656
Goethe University Frankfurt · DE

Funding

Deutsche Forschungsgemeinschaft Graduate college CLICDeutsche Forschungsgemeinschaft Graduate College CLICDeutsche Forschungsgemeinschaft SFB 902Hessisches Ministerium für Wissenschaft und Kunst BMRZ
6 · The paper itself

Abstract

Ribonucleic acid oligonucleotides (RNAs) play pivotal roles in cellular function (riboswitches), chemical biology applications (SELEX-derived aptamers), cell biology and biomedical applications (transcriptomics). Furthermore, a growing number of RNA forms (long non-coding RNAs, circular RNAs) but also RNA modifications are identified, showing the ever increasing functional diversity of RNAs. To describe and understand this functional diversity, structural studies of RNA are increasingly important. However, they are often more challenging than protein structural studies as RNAs are substantially more dynamic and their function is often linked to their structural transitions between alternative conformations. NMR is a prime technique to characterize these structural dynamics with atomic resolution. To extend the NMR size limitation and to characterize large RNAs and their complexes above 200 nucleotides, new NMR techniques have been developed. This Minireview reports on the development of NMR methods that utilize detection on low-γ nuclei (heteronuclei like

Indexed as

Nuclear Magnetic Resonance, BiomolecularCarbon IsotopesIsotope LabelingNitrogen IsotopesProtonsRNACarbon-13Carbon IsotopesNitrogen-15Nitrogen IsotopesProtonsRNAcarbon direct detectionheteronuclear detectionnitrogen direct detectionNMRRNA

Identifiers

PMID31454110
PMCPMC6973061
OpenAlexW2970141233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.