ArticleeLife2019
Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.
Abstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Genomic basis of adaptation to cardiac glycosides in three insect orders.Frontiers in genetics · 2026Article
- Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.Nature ecology & evolution · 2025Article
- Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein.bioRxiv : the preprint server for biology · 2025Article
- The shape of discovery: a journey through genetics, coevolution, and a scientific life.Genetics · 2025Article
- Convergent Evolution and Predictability of Gene Copy Numbers Associated with Diets in Mammals.Genome biology and evolution · 2025Article
- Phylogenomics of Tetraopes longhorn beetles unravels their evolutionary history and biogeographic origins.Scientific reports · 2024Article
- Fecal Deployment: An Alternative Way of Defensive Host Plant Cardenolide Use by Lilioceris merdigera Larvae.Journal of chemical ecology · 2024Article
- Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistance strategies.Current biology : CB · 2023Article
- Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistance strategies.bioRxiv : the preprint server for biology · 2023Article
- Convergent resistance to GABA receptor neurotoxins through plant-insect coevolution.Nature ecology & evolution · 2023Article
- Tissue-specific plant toxins and adaptation in a specialist root herbivore.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- New Structures, Spectrometric Quantification, and Inhibitory Properties of Cardenolides fromMolecules (Basel, Switzerland) · 2022Article
- Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander.iScience · 2022Article
- Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases.Molecular biology and evolution · 2022Article
- Defence mitigation by predators of chemically defended prey integrated over the predation sequence and across biological levels with a focus on cardiotonic steroids.Royal Society open science · 2022Review
- RETRACTED: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence.PLoS genetics · 2022Article
- Functional evidence supports adaptive plant chemical defense along a geographical cline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
- Convergent evolution of cardiac-glycoside resistance in predators and parasites of milkweed herbivores.Current biology : CB · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Andrew M TavernerLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.ORCID 0000-0001-8265-6836
Lu YangDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.ORCID 0000-0002-2694-1189
Zachary J BarileDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Becky LinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Julie PengLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.
Ana P PinharandaDepartment of Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-4696-9218
Arya S RaoDepartment of Biological Sciences, Columbia University, New York, United States.ORCID 0000-0003-3007-4812
Bartholomew P RolandDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Aaron D TalsmaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Daniel WeiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Georg PetschenkaInstitute for Insect Biotechnology, Justus-Liebig-Universität Gießen, Hesse, Germany.
Michael J PalladinoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, United States.
Peter AndolfattoDepartment of Biological Sciences, Columbia University, New York, United States.ORCID 0000-0003-3393-4574
Funding
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4MParallel evolution at Na,K-ATPase: a model system for understanding constraints on the evolution of novel protein functions.R01GM115523 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER · 2015 to 2024
$2.8MPre-clinical studies of novel mitochondrial gene therapiesR01GM108073 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PALLADINO, MICHAEL JOHN · 2015 to 2018
$1.1MMitochondrial Dysfunction and Progressive EncephalomyopathiesR01AG027453 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PALLADINO, MICHAEL JOHN · 2009 to 2010
$758kNIA NIH HHS R01 AG027453NIGMS NIH HHS R01 GM108073NIGMS NIH HHS R01 GM115523NIGMS NIH HHS T32 GM008424
Abstract
Predicting how species will respond to selection pressures requires understanding the factors that constrain their evolution. We use genome engineering of
Indexed as
Adaptation, BiologicalEpistasis, GeneticInsecticide ResistanceAnimalsCardiac GlycosidesDrosophilaInsecticidesCardiac GlycosidesInsecticidesadaptationD. melanogasterecological geneticsepistasisevolutionary biologynatural selectionpleiotropyprotein evolution
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.