Evidence map›Paper›PMID 31453710›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice.

Jerad H Dumolt, Min Ma, Joyce Mathew, Mulchand S Patel, Todd C Rideout

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  4. Review
  5. Article
  6. The Genetics of Alzheimer's Disease in the Chinese Population.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jerad H DumoltDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.
Min MaDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.
Joyce MathewDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.
Mulchand S PatelBiochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.
Todd C RideoutDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.
University at Buffalo, State University of New York · US

Funding

Cardiovascular Protection by Phytosterols in Dyslipidemic Mothers and ProgenyK01AT007826 · NCCIH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RIDEOUT, TODD · 2013 to 2017
$724k
NCCIH NIH HHS K01 AT007826
6 · The paper itself

Abstract

Maternal hypercholesterolemia (MHC) is a pathological condition characterized by an exaggerated rise in maternal serum cholesterol during gestation, which can alter offspring hepatic lipid metabolism. However, the extent that these maladaptations occur during gestation and the molecular mechanisms involved remain unknown. MicoRNAs (miRNA) are small, noncoding RNAs that contribute to the development and progression of nonalcoholic fatty liver disease. Therefore, we sought to determine the degree to which in utero exposure to excessive cholesterol affects fetal hepatic lipid metabolism and miRNA expression. Twelve female apoE

Indexed as

AnimalsApolipoproteins ECholesterol, DietaryFemaleFetusHypercholesterolemiaLipid MetabolismLiverMiceMice, KnockoutMicroRNAsPlacentaPregnancyPregnancy, AnimalTriglyceridesApolipoproteins ECholesterol, DietaryMicroRNAsTriglyceridesmaternal hypercholesterolemiamiRNAnonalcoholic fatty liver diseaseplacentapregnancy

Identifiers

PMID31453710
PMCPMC6879864
OpenAlexW2970318458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.