Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs.

Chunhong Dong, Shuanglin Liu, Xiaodong Cheng, Qiang Wang, Shiqing Jiang, Guoqing Wang

Open access · goldAbstract read

In one paragraph

Article in BMC chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

1.3field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

Study on the chemical reactivity difference of primary hydroxyl groups in iridoid glycosides.RSC advances · 2023
Article
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.Drug design, development and therapy · 2022
Article
Design, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy.Scientific reports · 2020
Article
Determination of behavior of catalpol hexapropionate in simulated gastric conditions by UPLC-ESI-HRMS.Scientific reports · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chunhong Dong1Henan University of Chinese Medicine, Zhengzhou, 450046 Henan China.

Shuanglin Liu1Henan University of Chinese Medicine, Zhengzhou, 450046 Henan China.

Xiaodong Cheng2Department of Applied Chemistry, Zhengzhou University of Light Industry, Zhengzhou, 450002 Henan China.

Qiang Wang3High & New Technology Research Center of Henan Academy of Sciences, Zhengzhou, 450002 Henan China.

Shiqing Jiang1Henan University of Chinese Medicine, Zhengzhou, 450046 Henan China.

Guoqing Wang2Department of Applied Chemistry, Zhengzhou University of Light Industry, Zhengzhou, 450002 Henan China.ORCID 0000-0002-9239-2819

First Affiliated Hospital of Henan University · CNZhengzhou University of Light Industry · CNHenan Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (Total_score) and C log

Indexed as

Antiaging drugCatalpol propionateMolecular dockingSynthesis

Identifiers

PMID31453572

DOI10.1186/s13065-019-0626-3

PMCPMC6702743

OpenAlexW2969533405

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.