ArticleTurkish journal of physical medicine and rehabilitation2018
Effect of vitamin D levels on radiographic knee osteoarthritis and functional status.
Article in Turkish journal of physical medicine and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06267053 (Investigation of the Relationship Between Vitamin B12, Folic Acid and 25 OH D Levels and Radiologic Stage in Knee Osteoarthritis), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Relationship Between Vitamin B12, Folic Acid and 25 OH D Levels and Radiologic Stage in Knee Osteoarthritis
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Association of Vitamin D Status with Radiographic Changes in Knee Osteoarthritis Patients.Cureus · 2026Article
- Is there a relationship between blood inflammation markers and the severity of knee osteoarthritis?Turkish journal of physical medicine and rehabilitation · 2025Article
- The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database.Scientific reports · 2024Article
- Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review.Clinics and practice · 2024Review
- Article
- Vitamin D and its association with symptom severity in knee osteoarthritis: a cross sectional study at a national referral hospital in Uganda.BMC rheumatology · 2021Article
- Vitamin D deficiency, functional status, and balance in older adults with osteoarthritis.World journal of clinical cases · 2021Article
- Association between serum Vitamin D deficiency and Knee Osteoarthritis.Mediterranean journal of rheumatology · 2019Article
- Vitamin D in the Prevention and Treatment of Osteoarthritis: From Clinical Interventions to Cellular Evidence.Nutrients · 2019Review
- Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development.BioMed research international · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to investigate the effect of serum levels of 25 hydroxyvitamin D (25(OH)D) in patients with primary knee osteoarthritis (OA) and to assess its relationship with the radiographic grading and functional status. PATIENTS AND
methodsSerum 25(OH)D levels were measured in 107 patients (90 females, 17 males; mean age 63.0±9.6 years; range, 40 to 86 years) with primary knee OA. Radiographic grading was based on the Kellgren-Lawrence Grading Scale and the Osteoarthritis Research Society International (OARSI) Atlas Grading Scale, while the functional status was assessed using the Lequesne indices and Turkish version of the Knee Injury and Osteoarthritis Outcome Score-Physical Function Short-Form (KOOS-PS). Pain was evaluated using the Visual Analog Scale for Pain (VAS-Pain). Data including age, sex, disease duration, body mass index (BMI), and pain severity were recorded.
resultsThe mean 25(OH)D level was 13.4±10.6 ng/mL, and 90 patients (84.1%) had vitamin D deficiency. The presence of severe osteophytes was observed in 67 patients (62.6%) and 85 patients (79.4%) had Grade 2-3 joint space narrowing (JSN). The mean KOOS-PS and Lequesne scores were 40.1±12.3 and 12.9±3.6, respectively. There was no correlation between serum 25(OH)D levels and functional status.
conclusionOur study results show that serum 25(OH)D level is not related to the severity of the radiographic knee OA grading or to the functional assessment. Age and BMI are the factors affecting the radiological knee OA severity, while age, sex, BMI, and pain severity are the main determinants of the functional status.
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