ArticleTurkish journal of physical medicine and rehabilitation2017
The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model.
Article in Turkish journal of physical medicine and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- The Early Effect of Alendronate, Hop Extract and Their Combination on Bone Structural Properties in a Rat Model of Osteoporosis.Medical sciences (Basel, Switzerland) · 2026Article
- Evaluation of bone-protecting effects of palm carotene mixture in two- and three-dimensional osteoblast/osteoclast co-culture systems.International journal of medical sciences · 2025Article
- Bisphosphonate's effect on the tongue in adult male albino rats and the possible protective role of rutin: light and scanning electron microscopic study.Anatomy & cell biology · 2024Article
- Myricitrin: A promising herbal therapy for periodontitis in immunosuppressed status.The Saudi dental journal · 2023Article
- Topical application of the plant extract SDTL-E in ovariectomized rats: A potential new approach for treating osteoporosis.Frontiers in medicine · 2022Article
- Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies.International journal of molecular sciences · 2020Review
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTObjectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. MATERIALS AND
methodsBetween May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days.
resultsDensitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less well- formed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05).
conclusionOur study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.
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