Evidence map›Paper›PMID 31453433›Full record

ArticleEpigenetics insights2019

DNA Methylation Trajectories During Pregnancy.

Olena Gruzieva, Simon Kebede Merid, Su Chen, Nandini Mukherjee, Anna M Hedman, Catarina Almqvist, Ellika Andolf, Yu Jiang, Juha Kere, Annika Scheynius and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Epigenetics insights, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Pregnancy is linked to faster epigenetic aging in young women.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. DNA methylation dynamics during pregnancy.Frontiers in cell and developmental biology · 2023
    Article
  16. Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event.International journal of molecular sciences · 2022
    Review
  17. Association of pregnancies with risk of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Article
  18. CD4Epigenetics · 2022
    Article
  19. Associations between epigenetic age acceleration and infertility.Human reproduction (Oxford, England) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Olena GruzievaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-4147-5654
Simon Kebede MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Su ChenDivision of Epidemiology, Biostatistics, and Environmental Health Science, School of Public Health, The University of Memphis, Memphis, TN, USA.
Nandini MukherjeeDivision of Epidemiology, Biostatistics, and Environmental Health Science, School of Public Health, The University of Memphis, Memphis, TN, USA.
Anna M HedmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ellika AndolfDepartment of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Yu JiangDivision of Epidemiology, Biostatistics, and Environmental Health Science, School of Public Health, The University of Memphis, Memphis, TN, USA.
Juha KereDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Annika ScheyniusDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Cilla SöderhällDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health Science, School of Public Health, The University of Memphis, Memphis, TN, USA.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Syed Hasan ArshadThe David Hide Asthma and Allergy Research Centre, Newport, UK.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEUniversity of Memphis · USStockholm County Council · SEDavid Hide Asthma and Allergy Research Centre · GBKarolinska University Hospital · SEScience for Life Laboratory · SEUniversity of Helsinki · FI

Funding

Effect of Prenatal Compounds on Adult Lung Function via Neonatal DNA MethylationR01HL132321 · NHLBI · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2016 to 2020
$3.2M
Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
NHLBI NIH HHS R01 HL132321NIAID NIH HHS R01 AI091905
6 · The paper itself

Abstract

There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome-wide longitudinal DNAm study of a well-characterized sample of young women from the Swedish Born into Life study, with repeated blood sampling before, during and after pregnancy (n = 21), using the Illumina Infinium MethylationEPIC array. We conducted a replication in the Isle of Wight third-generation birth cohort (n = 27), using the Infinium HumanMethylation450k BeadChip. We identified 196 CpG sites displaying intra-individual longitudinal change in DNAm with a false discovery rate (FDR)

Indexed as

CohortDNA methylationIllumina EPIC and Infinium chippregnancy

Identifiers

PMID31453433
PMCPMC6696836
OpenAlexW2968524855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.