Evidence map›Paper›PMID 31453424›Full record

ArticleCurrent developments in nutrition2019

Impact of a High Intake of Dairy Product on Insulin Sensitivity in Hyperinsulinemic Adults: A Crossover Randomized Controlled Trial.

Sarah O'Connor, Pierre Julien, Stanley John Weisnagel, Claudia Gagnon, Iwona Rudkowska

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02961179 (Nutrigenomics Approach to Investigate the Benefits of Dairy Product Consumption on Glucose Homeostasis), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02961179 nacompletednot on this map

Nutrigenomics Approach to Investigate the Benefits of Dairy Product Consumption on Glucose Homeostasis

TypeinterventionalSponsorCHU de Quebec-Universite LavalRan2017 to 2018Enrolled33ConditionsInsulin Sensitivity, Type2 DiabetesArmsIncreased dairy product, Dietary counselling
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah O'ConnorEndocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.ORCID 0000-0003-3361-8192
Pierre JulienEndocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.
Stanley John WeisnagelEndocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.
Claudia GagnonEndocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.ORCID 0000-0001-9623-962X
Iwona RudkowskaEndocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.ORCID 0000-0003-2392-564X
Centre hospitalier universitaire de Québec · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDairy product intake has been associated with decreased risk of type 2 diabetes (T2D) in cohort studies. However, results from clinical trials on T2D-related risk factors remain inconclusive.

objectiveThe aim of this clinical trial was to evaluate the impact of high dairy product intake (HD) (≥4 servings/d) for 6 wk, compared with an adequate dairy product intake (AD) (≤2 servings/d), on glycemic and insulinemic parameters, insulin sensitivity, insulin secretion, and β-cell function in hyperinsulinemic adults.

methodsIn this crossover clinical trial, hyperinsulinemic adults were randomly assigned to HD or AD for 6 wk, then crossed over after a 6-wk washout period. Serum glucose, insulin, C-peptide, HOMA-IR, Matsuda index, insulinogenic index, and disposition index were measured and analyzed using a repeated-measures mixed model adjusted for age, sex, and BMI. Anthropometric measures were collected and food intake was evaluated using a validated FFQ.

resultsNineteen men and 8 women completed the study (mean ± SD age: 55 ± 14 y; BMI: 31.3 ± 3.3 kg/m

conclusionsHD does not affect glycemic and insulinemic parameters, insulin sensitivity, insulin secretion, and β-cell function over AD in hyperinsulinemic adults. Additional larger and longer studies assessing T2D-related risk factors are required. This trial was registered at clinicaltrials.gov as NCT02961179.

Indexed as

cheesehyperinsulinemiainsulin resistanceinsulin secretionmilkprediabetesyogurtβ-cell function

Identifiers

PMID31453424
PMCPMC6700456
OpenAlexW2965450014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.