Evidence map›Paper›PMID 31453412›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2019

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways.

Marissa B Kosnik, Antonio Planchart, Skylar W Marvel, David M Reif, Carolyn J Mattingly

Abstract read
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marissa B KosnikToxicology Program, North Carolina State University, North Carolina State University, Raleigh, NC 27695-7617, United States.
Antonio PlanchartToxicology Program, North Carolina State University, North Carolina State University, Raleigh, NC 27695-7617, United States.
Skylar W MarvelBioinformatics Research Center, North Carolina State University, North Carolina State University, Raleigh, NC 27695-7617, United States.
David M ReifToxicology Program, North Carolina State University, North Carolina State University, Raleigh, NC 27695-7617, United States.
Carolyn J MattinglyToxicology Program, North Carolina State University, North Carolina State University, Raleigh, NC 27695-7617, United States.

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
The Comparative Toxicogenomics Database (CTD)R01ES014065 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAVIS, ALLAN PETER, MATTINGLY, CAROLYN J. · 2006 to 2021
$10.5M
TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGYT32ES007046 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Seth William Kullman · 1985 to 2026
$5.1M
Advancing mechanism-based studies with cross-species chemical-phenotype dataR01ES023788 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MATTINGLY, CAROLYN J. · 2015 to 2019
$1.6M
Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput ScreeningR56ES030007 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI REIF, DAVID M · 2019 to 2019
$225k
EPA R835802NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R01 ES014065NIEHS NIH HHS R01 ES023788NIEHS NIH HHS R56 ES030007NIEHS NIH HHS T32 ES007046
6 · The paper itself

Abstract

Addressing the complex relationship between public health and environmental exposure requires multiple types and sources of data. An important source of chemical data derives from high-throughput screening (HTS) efforts, such as the Tox21/ToxCast program, which aim to identify chemical hazard using primarily

Indexed as

CTDData integrationDiseaseDisease pathwaysToxCast

Identifiers

PMID31453412
PMCPMC6709694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.