Evidence map›Paper›PMID 31453381›Full record

ArticleCommunications biology2019

Adipocyte metabolism is improved by TNF receptor-targeting small RNAs identified from dried nuts.

Katia Aquilano, Veronica Ceci, Angelo Gismondi, Susanna De Stefano, Federico Iacovelli, Raffaella Faraonio, Gabriele Di Marco, Noemi Poerio, Antonella Minutolo, Giuseppina Minopoli and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Katia Aquilano1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Veronica Ceci1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Angelo Gismondi1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Susanna De Stefano2Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, Italy.
Federico Iacovelli1Department of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0001-7511-6575
Raffaella Faraonio3Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.
Gabriele Di Marco1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Noemi Poerio1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Antonella Minutolo1Department of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0003-4784-4297
Giuseppina Minopoli3Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.
Antonia Marcone3Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.
Maurizio Fraziano1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Flavia Tortolici1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Simona Sennato4CNR-ISC and Department of Physics, Sapienza University of Rome, Piazzale A. Moro 2, 00185 Rome, Italy.
Stefano Casciardi5Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, National Institute for Insurance against Accidents at Work (INAIL) Research, Rome, Italy.
Marina Potestà1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Roberta Bernardini6Interdepartmental Service Center-Station for Anima Technology (STA), University of Rome Tor Vergata, Rome, Italy.
Maurizio Mattei1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Mattia Falconi1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Carla Montesano1Department of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-9865-6619
Stefano Rufini1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Antonella Canini1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Daniele Lettieri-Barbato1Department of Biology, University of Rome Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · ITFederico II University Hospital · ITIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing interest in therapeutically targeting the inflammatory response that underlies age-related chronic diseases including obesity and type 2 diabetes. Through integrative small RNA sequencing, we show the presence of conserved plant miR159a and miR156c in dried nuts having high complementarity with the mammalian TNF receptor superfamily member 1a (Tnfrsf1a) transcript. We detected both miR159a and miR156c in exosome-like nut nanovesicles (NVs) and demonstrated that such NVs reduce Tnfrsf1a protein and dampen TNF-α signaling pathway in adipocytes. Synthetic single-stranded microRNAs (ss-miRs) modified with 2'-

Indexed as

Desiccation3T3-L1 CellsAdipocytesAdipose TissueAnimalsCytokinesFemaleGene Expression Regulation, PlantGlucoseHEK293 CellsHumansHypertrophyInflammationInsulinMiceMice, Inbred C57BLCytokinesGlucoseInsulinMicroRNAsReceptors, Tumor Necrosis FactorRNA, MessengerRNA, PlantDisease modelMetabolismMolecular medicine

Identifiers

PMID31453381
PMCPMC6704100
OpenAlexW2969337025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.