Evidence map›Paper›PMID 31453348›Full record

ArticleLaryngoscope investigative otolaryngology2019

PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy.

Leonie Bruine de Bruin, Jan E Wachters, Michiel L Schrijvers, Lorian Slagter-Menkema, Mirjam F Mastik, Johannes A Langendijk, Jacqueline E van der Wal, Ed Schuuring, Bernard F A M van der Laan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Leonie Bruine de BruinDepartment of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.ORCID https://orcid.org/0000-0003-1240-9236
Jan E WachtersDepartment of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.
Michiel L SchrijversDepartment of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.
Lorian Slagter-MenkemaDepartment of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.
Mirjam F MastikGraduate School of Medical Sciences (Groningen University Institute for Drug Exploration) University of Groningen Groningen The Netherlands.
Johannes A LangendijkGraduate School of Medical Sciences (Groningen University Institute for Drug Exploration) University of Groningen Groningen The Netherlands.
Jacqueline E van der WalDepartment of Pathology and Medical Biology University Medical Center Groningen, University of Groningen Groningen The Netherlands.
Ed SchuuringGraduate School of Medical Sciences (Groningen University Institute for Drug Exploration) University of Groningen Groningen The Netherlands.
Bernard F A M van der LaanDepartment of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to establish the prognostic value of the epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on local control in patients with early stage supraglottic laryngeal squamous cell carcinoma (LSCC) treated with radiotherapy only. STUDY

designRetrospective cohort study.

methodsImmunohistochemical staining for EGFR and PTEN was performed on pretreatment biopsies of a selected well-defined homogeneous group of 52 patients with T1-T2 supraglottic LSCC treated with radiotherapy between 1990 and 2008. Kaplan-Meier analysis and univariate and multivariate Cox Regression analyses were performed to correlate clinical data and expression levels of EGFR and PTEN with local control.

resultsKaplan-Meier survival analysis and Cox Regression analysis showed a significant association between PTEN expression and local control (hazard ratio [HR] = 3.26, 95% confidence interval [CI] = 1.14-9.33,

conclusionThis study showed an association between both high PTEN expression and the presence of lymph node metastasis and deteriorated local control in early stage supraglottic LSCC treated with radiotherapy. LEVEL OF EVIDENCE: NA.

Indexed as

EGFRlaryngeal squamous cell carcinomalocal controlPTENradiotherapy

Identifiers

PMID31453348
PMCPMC6703112
OpenAlexW2952282937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.