Evidence map›Paper›PMID 31453182›Full record

ArticleJournal of advanced veterinary and animal research2019

Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone.

Ivan A Arkhipov, Salavat S Khalikov, Konstantin M Sadov, Alexander V Dushkin, Elizaveta S Meteleva, Anastasiya I Varlamova, Irina M Odoevskaya, Nataliya V Danilevskaya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced veterinary and animal research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anthelmintics for drug repurposing: Opportunities and challenges.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ivan A ArkhipovDepartment of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia.
Salavat S KhalikovDepartment of Physiologically Active Organofluorine Compounds, A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia.
Konstantin M SadovDepartment of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia.
Alexander V DushkinDepartment of Mechanochemistry of Organic Compounds, Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Elizaveta S MetelevaDepartment of Mechanochemistry of Organic Compounds, Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Anastasiya I VarlamovaDepartment of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia.
Irina M OdoevskayaDepartment of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia.
Nataliya V DanilevskayaDepartment of Pharmacology and Toxicology, Moscow State Academy of Veterinary Medicine and Biotechnology, MVA named after K.I. Skryabin, Moscow, Russia.
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin · RUInstitute of Solid State Chemistry and Mechanochemistry · RUA. N. Nesmeyanov Institute of Organoelement Compounds · RUMoscow State Academy of Veterinary Medicine and Biotechnology named after Skryabin · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of our research was to evaluate the effect of mechanochemical technology on the efficacy of supramolecular complex of fenbendazole (SMCF) with polyvinylpyrrolidone (PVP) polymer against some helminthosis of animals. MATERIALS AND

methodsThe SMCF samples with PVP were synthesized using a solid-state mechanochemical technology in activators of impact-abrading type and their physicochemical properties were analyzed. The efficacy of SMCF was studied on the laboratory model of

resultsIn the trials conducted on laboratory models, the supramolecular complex showed 93.94% and 98.56 % efficacy at the dose of 1 mg/kg of body weight (b/w), while the substance of fenbendazole showed 7.97% and 8.33% efficacy at the same dose. A high efficacy (>94%) of the SMCF was revealed at the dose of 2.0 mg/kg of b/w at oral administration against nematodes in naturally infected sheep by the results of the fecal examination, while the substance of fenbendazole was active at the dose of 5.0 mg/kg at single oral administration. Moreover, the SMCF demonstrated 97.37% efficacy at the dose of 2 mg/kg against

conclusionAccording to the results, supramolecular complex of fenbendazole with PVP was more active than the basic substance of fenbendazole and its anthelmintic properties were expanded.

Indexed as

Efficacyfenbendazolemechanochemistrypolyvinylpyrrolidone polymersupramolecular complex

Identifiers

PMID31453182
PMCPMC6702931
OpenAlexW2920631267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.