Evidence map›Paper›PMID 31453129›Full record

ArticleJournal of traditional and complementary medicine2019

Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3β.

Hironori Fujiwara, Jun Yoshida, Dya Fita Dibwe, Suresh Awale, Haruka Hoshino, Hiroshi Kohama, Hiroyuki Arai, Yukitsuka Kudo, Kinzo Matsumoto

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hironori FujiwaraInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Jun YoshidaInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Dya Fita DibweInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Suresh AwaleInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Haruka HoshinoInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Hiroshi KohamaInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
Hiroyuki AraiDepartment of Geriatric and Respiratory Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Yukitsuka KudoDepartment of Geriatric and Respiratory Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kinzo MatsumotoInstitute of Natural Medicine, University of Toyama, Toyama, Japan.
University of Toyama · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe aging-dependent activation of glycogen synthase kinase-3β (GSK-3β) has been suggested to be important in the onset of dementia. To discover novel therapeutic Kampo medicines for dementia, we examined the effects of orengedokuto (OGT; huáng lián jiědú tāng) and san'oshashinto (SST; sān huáng xiè xīn tāng) on memory deficits and GSK-3β activity in senescence-accelerated prone mice (SAMP8). EXPERIMENTAL PROCEDURE: The object recognition test (ORT) and conditioned fear memory test (CFT) were employed to elucidate short-term working memory and long-term fear memory. The activity of GSK-3β and the phosphorylation of related molecules were measured using a kinase assay and Western blotting. RESULTS AND

conclusionOGT and SST attenuated memory deficits in SAMP8 in ORT, but not in CFT. In

Indexed as

AD, Alzheimer's diseaseAlzheimer's diseaseBPSD, behavioral and psychological symptoms of dementiaCFT, conditioned fear memory testCollapsin response mediator protein-2CRMP2, collapsin response mediator protein-2Glycogen synthase kinase-3βGSK-3β, glycogen synthase kinase-3βOGT, orengedokutoOrengedokutoORT, object recognition testSAMP8, senescence-accelerated prone mice 8SAMR1, senescence-accelerated prone mice-resistantsan'oshashintoSST, san'oshashinto

Identifiers

PMID31453129
PMCPMC6702137
OpenAlexW2907409902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.