ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed.
- Tailored construction and functional applications of conductive hydrogels for bioelectronic interfaces.Discover nano · 2026Review
- Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms.Chemical record (New York, N.Y.) · 2026Review
- Bio-Inspired Adhesive Hydrogels for Localized Therapeutic Delivery: From Catechol Chemistry to Smart Biointerfaces.Biomimetics (Basel, Switzerland) · 2026Review
- Reversible Cationic Glycopolymer Hydrogels for RNA Delivery in Ticks.ACS polymers Au · 2026Article
- Dynamic Organic-Inorganic Interpenetrating Nanonetwork for Stiff and Durable Flexible Material.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A pH‑responsive hydrogel delivering ISOC1 modRNA attenuates disc degeneration by promoting BIRC6‑mediated MYC degradation and inhibiting SBSN expression.Journal of nanobiotechnology · 2026Article
- Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications.Exploration (Beijing, China) · 2026Review
- Self-Healing and pH-Robust Hydrogels Enabled by Synergistic Supramolecular Interactions for Injectable Gastrointestinal Wound Repair.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Microalgae as a Novel Therapy for Chronic Wound Healing.International wound journal · 2026Review
- Review
- Advancing transdermal drug delivery through 4D bioprinting and dynamic skin modelling.Frontiers in drug delivery · 2026Review
- Musculoskeletal ultrasound-guided cellular therapy: Current applications and future directions in skeletal muscle regeneration.Iranian journal of basic medical sciences · 2026Review
- Deciphering skin architecture, wound pathophysiology and molecular mechanisms of healing: insights into immune response and therapeutic strategies.Frontiers in bioengineering and biotechnology · 2026Review
- Metformin-Embedded Hydrogels: A Promising Approach for Accelerating Healing in Diabetic Ulcers.Current drug delivery · 2026Article
- Extensile Active Hydrogels Driven by Living FtsZ Polymers.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Biocompatible Stimuli-Sensitive Natural Hydrogels: Recent Advances in Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Review
- Additive-free hyaluronic acid-based bioink for 3D bioprinting of bone marrow microenvironments.Materials today. Bio · 2025Article
- Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Rational Design of Self-Healing Hydrogel with High Mechanical Strength and Self-Healing Efficiency: A Short Review.Gels (Basel, Switzerland) · 2025Review
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given their durability and long-term stability, self-healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self-healing remains unaddressed, and therefore most of the self-healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self-healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double-network hydrogels is showing great promise as a feasible way to generate self-healable hydrogels with the above-mentioned attributes. Here, the recent progress in the development of multifunctional and self-healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.