ArticleBiomedical optics express2019
Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications.Journal of biomedical optics · 2022Pooled it
- Identification and quantification of oral lymphatic vessel networks using optical coherence tomography (OCT).Biomedical optics express · 2026Article
- Optical coherence tomography for label-free detection and characterization of methicillin-resistantJournal of biomedical optics · 2025Article
- Detection and differentiation of semi-transparent materials simulating biological structures using optical coherence tomography: a phantom study.Journal of biomedical optics · 2022Article
- Review
- Statistical analysis of corneal OCT speckle: a non-parametric approach.Biomedical optics express · 2021Article
- Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography.Biomedical optics express · 2021Article
- Lymphatic vessel segmentation in optical coherence tomography by adding U-Net-based CNN for artifact minimization.Biomedical optics express · 2020Article
- Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation.Journal of biomedical optics · 2020Review
- Article
- Recent progress in optical probing and manipulation of tissue: introduction.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering biological structures of interest. In a human tumor xenograft murine model, we show that these correspond to lymphatic vessels and nerves; extensive histopathologic validation studies are reported to unequivocally establish this correspondence. The emerging possibility of OCT lymphangiography and neurography is novel and potentially impactful (especially the latter), although further methodology refinement is needed to distinguish between the visualized lymphatics and nerves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.