Evidence map›Paper›PMID 31452998›Full record

ArticleBiomedical optics express2019

Phenomenon of atypical vascular effects of epinephrine and an increase of photodynamic response by nitroglycerin in rats with colon adenocarcinoma: adrenergic and nitrergic mechanisms and novel applied aspects.

Ilana Agranovich, Ekaterina Borisova, Nikita Navolokin, Alla Bucharskaya, Galina Maslyakova, Alexander Shirokov, Arkady Abdurashitov, Ivan Angelov, Alexander Khorovodov, Andrey Terskov and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ilana AgranovichSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Ekaterina BorisovaSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Nikita NavolokinSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Alla BucharskayaSaratov State Medical University, Bolshaya Kazachia str. 112, Saratov 410012, Russia.
Galina MaslyakovaSaratov State Medical University, Bolshaya Kazachia str. 112, Saratov 410012, Russia.
Alexander ShirokovSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Arkady AbdurashitovSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Ivan AngelovInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bontchev str. Bl. 9,1113 Sofia, Bulgaria.
Alexander KhorovodovSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Andrey TerskovSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Aysel MamedovaSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Maria KlimovaSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Oxana Semyachkina-GlushkovskayaSaratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Saratov State University · RUSaratov State Medical University · RUInstitute of Organic Chemistry with Centre of Phytochemistry · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using an original model of stress-induced colon adenocarcinoma, we uncover atypical vasorelaxation effects of a mucosa injection of epinephrine assessed by laser speckle contrast imaging and a significant increase of fluorescent intensity of 5-ALA/PpIX from malignant colon tissues by a mucosa injection of nitroglycerine. We clearly demonstrate a high activity of adrenergic and nitrergic mechanisms underlying this phenomenon and discuss their application in improving of optical approaches for effective diagnosis of gastrointestinal cancer.

Identifiers

PMID31452998
PMCPMC6701521
OpenAlexW2959556581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.