ArticleBiomedical optics express2019
Enhanced resolution 3D digital cytology and pathology with dual-view inverted selective plane illumination microscopy.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
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- Article
- Rapid On-Site Microscopy and Mapping of Diagnostic Biopsies for See-And-Treat Guidance of Localized Prostate Cancer Therapy.Cancers · 2023Article
- Assessment of photoacoustic tomography contrast for breast tissue imaging using 3D correlative virtual histology.Scientific reports · 2022Article
- Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.Journal of biomedical optics · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The current gold-standard histopathology for tissue analysis is destructive, time consuming, and limited to 2D slices. Light sheet microscopy has emerged as a powerful tool for 3D imaging of tissue biospecimens with its fast speed and low photo-damage, but usually with worse axial resolution and complicated configuration for sample imaging. Here, we utilized inverted selective plane illumination microscopy for easy sample mounting and imaging, and dual-view imaging and deconvolution to overcome the anisotropic resolution. We have rendered 3D images of fresh cytology cell blocks and millimeter- to centimeter-sized fixed tissue samples with high resolution in both lateral and axial directions. More accurate cellular quantification, higher image sharpness, and more image details have been achieved with the dual-view method compared with single-view imaging.
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Registered trials
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