Evidence map›Paper›PMID 31452955›Full record

ArticleClinical and experimental dental research2019

Profiling microorganisms in whole saliva of children with and without dental caries.

Alexandre R Vieira, N Luisa Hiller, Evan Powell, Leon Hak-Jin Kim, Tracy Spirk, Adriana Modesto, Rachael Kreft

Open access · goldAbstract read
In one paragraph

Article in Clinical and experimental dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Oral microbiome patterns of dental caries in Kazakhstani adolescents.Journal of applied oral science : revista FOB · 2025
    Article
  5. Microbiome variability and role ofJournal of oral microbiology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Correlation between caries activity and salivary microbiota in preschool children.Frontiers in cellular and infection microbiology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Outer membrane vesicles of the oral pathogenFrontiers in oral health · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexandre R VieiraDepartment of Oral Biology, School of Dental Medicine University of Pittsburgh Pittsburgh Pennsylvania.ORCID 0000-0003-3392-6881
N Luisa HillerCenter of Excellence for Biofilm Research Allegheny Health Network Research Institute Pittsburgh Pennsylvania.
Evan PowellCenter of Excellence for Biofilm Research Allegheny Health Network Research Institute Pittsburgh Pennsylvania.
Leon Hak-Jin KimDepartment of Biological Sciences Carnegie Mellon University Pittsburgh Pennsylvania.
Tracy SpirkCenter of Excellence for Biofilm Research Allegheny Health Network Research Institute Pittsburgh Pennsylvania.
Adriana ModestoDepartment of Pediatric Dentistry, School of Dental Medicine University of Pittsburgh Pittsburgh Pennsylvania.
Rachael KreftCenter of Excellence for Biofilm Research Allegheny Health Network Research Institute Pittsburgh Pennsylvania.ORCID 0000-0001-9817-8584
Allegheny Health Network · USUniversity of Pittsburgh · USCarnegie Mellon University · US

Funding

Genetics of CariesR01DE018914 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIEIRA, ALEXANDRE REZENDE · 2009 to 2013
$2.2M
Insights from Comparative Genomics for the Treatment of Pneumococcal InfectionsR00DC011322 · NIDCD · CARNEGIE-MELLON UNIVERSITY · PI HILLER, NATALIA LUISA · 2012 to 2014
$718k
NIDCD NIH HHS R00 DC011322NIDCR NIH HHS R01 DE018914
6 · The paper itself

Abstract

Objectives: Dental caries is a highly prevalent infectious disease that causes tooth decay. While no single bacterial species is causative of dental caries, the role of the oral microbiome in oral health and caries is gaining interest. The purpose of this study is to compare the major species present in whole saliva samples from caries-free and caries-active children using the IBIS Universal Biosensor. Material and Methods: The abundant microbial species in ninety-five whole saliva samples from caries-free and caries-active subjects were characterized using the IBIS Universal Biosensor. Results: Twenty-four genera and sixty-five species were detected. Conclusions: These study trends observed suggest that microbial markers in saliva may serve as predictors of oral health and thus aid in diagnosis and treatments for prevention of caries. Consistent with competitive interactions, we also observed negative associations between

Indexed as

AdolescentBacteriaBiosensing TechniquesChildDental CariesDental PlaqueDNA, BacterialFemaleHumansMaleMicrobiotaRNA, Ribosomal, 16SSalivaYoung AdultDNA, BacterialRNA, Ribosomal, 16ScariesIBIS Universal BiosensormicrobiotaStreptococcuswhole saliva

Identifiers

PMID31452955
PMCPMC6704248
OpenAlexW2951937314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.