ArticleAnnals of medicine and surgery (2012)2019
Diagnosis and treatment of Langerhans Cell Histiocytosis with bone lesion in pediatric patient: A case report.
Article in Annals of medicine and surgery (2012), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature.Orphanet journal of rare diseases · 2021Pooled it
- Eosinophilic granuloma: Case-report of spontaneous resolution.Radiology case reports · 2025Article
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- Mandibular unifocal Langerhans cell histiocytosis in a child - Report of successful management of a rare condition.International journal of surgery case reports · 2023Article
- Multifocal eosinophilic granuloma with femoral epiphyseal lesion mimicking an aneurysmal bone cyst.Radiology case reports · 2022Article
- Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases.The Journal of international medical research · 2022Article
- Role ofQuantitative imaging in medicine and surgery · 2022Article
- Adult Langerhans Cell Histiocytosis and the Skeleton.Journal of clinical medicine · 2022Review
- First technical report of a pediatric case with thoracic Langerhans cell histiocytosis: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage.Journal of craniovertebral junction & spineArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLangerhans cell histiocytosis (LCH) is a rare group of disorders without a well understood etiology. Known formerly as histiocytosis X, the disease has a wide spectrum of clinical presentations, including eosinophilic granuloma (solitary bone lesion), diabetes insipidus, and exophthalmos. Many of these patients initially present to orthopaedic surgeons, and misdiagnosis is frequent.
methodsWe deliver a case of a 10-month-old boy who consulted to our department. Previously misdiagnosed as a Kawasaki syndrome, TORCH, and osteomyelitis. He had undergone several examinations and had been discussed in clinocipathological conference (CPC) to narrow down the diagnosis.
resultAfter serial examinations, the diagnosis of Langerhans Cell Histiocytosis was confirmed and chemotherapy was initiated. And after 6 cycles of chemotherapy, with 1-week interval of each therapy, the clinical appearance of this patient significantly improved.
conclusionDespite major advances in our understanding and management of LCH, it remains one of the most challenging diagnoses for the orthopedic surgeon. By doing a comprehensive examination, it is possible to narrowing down the diagnosis and planning the accurate treatment.
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