ReviewTherapeutic advances in chronic disease2019
Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life.
Review in Therapeutic advances in chronic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06783010 (Sviluppo di Uno Score di Rischio Multidimensionale Basato Sui Deficit Sensoriali, Con un Approccio in Ensemble Learning, Per il Deterioramento Cognitivo in Una Coorte di Anziani Dell'Italia Meridionale), which is not on this map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sviluppo di Uno Score di Rischio Multidimensionale Basato Sui Deficit Sensoriali, Con un Approccio in Ensemble Learning, Per il Deterioramento Cognitivo in Una Coorte di Anziani Dell'Italia Meridionale
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Association of age-related hearing loss with cognitive impairment and dementia: an umbrella review.Frontiers in aging neuroscience · 2023Pooled it
- Pooled it
- Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis.Frontiers in psychology · 2021Pooled it
- Smartphone Apps in the Context of Tinnitus: Systematic Review.Sensors (Basel, Switzerland) · 2020Pooled it
- Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index.BMC geriatrics · 2022Trial
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.Scientific reports · 2020Trial
- Speech Perception in Noise: A Narrative Review of Cognitive Contribution and Hearing-Aid Signal Processing.Journal of Intelligence · 2026Review
- Associations between hearing and vision impairment and type 2 diabetes among middle-aged and older chinese adults: a nationwide longitudinal cohort study.Journal of health, population, and nutrition · 2026Observational
- Hearing Loss as a Potentially Modifiable Marker of Dementia Risk: Neurological Evidence, Uncertainty, and Clinical Interpretation.Neuro-degenerative diseases · 2026Review
- Systemic immune-inflammation index and neutrophil-to-lymphocyte ratio predict treatment responses in elderly patients with profound sudden deafness.Experimental and therapeutic medicine · 2026Article
- Distinct neural substrates of disease severity and cognitive impairment in COPD: a multimodal MRI study.BMC medical imaging · 2026Article
- The role of NLRP3 neuroinflammation in cognitive frailty diversity during aging and after LPS administration in mice.Scientific reports · 2026Article
- [Current status and future perspectives on age-related hearing loss and cognitive impairment].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.GeroScience · 2026Article
- Editorial: Tracing loneliness in aging: understanding the interplay and exploring innovative interventions.Frontiers in psychiatry · 2026Article
- Review
- Increased Listening Effort: Is Hearing Training a Solution?-Results of a Pilot Study on Individualized Computer-Based Auditory Training in Subjects Not (Yet) Fitted with Hearing Aids.Audiology research · 2025Article
- Hearing loss and cognitive impairment among older adults: findings from the China health and retirement longitudinal study.BMC public health · 2025Article
- Social Frailty and Social Isolation in the Context of Dementia: A Simultaneous Concept Analysis.International journal of geriatric psychiatry · 2025Review
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer's disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.