ArticleTherapeutic advances in chronic disease2019
Multimorbidity, inflammation, and disability: a longitudinal mediational analysis.
Article in Therapeutic advances in chronic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Multimorbidity in the Brazilian adult population: Protocol for a systematic review and meta-analysis of prevalence.PloS one · 2026Article
- Sexual Minority Identity and Physical Illnesses: Role of Life-Course Victimization and Gender Differences.American journal of preventive medicine · 2025Article
- Limited association between multimorbidity and high-sensitive C-reactive protein or gait speed in community-dwelling octogenarians - findings from the BUTTERFLY study.The journal of nutrition, health & aging · 2025Article
- Food insecurity, food assistance, and physical and cognitive functioning among older Americans.PloS one · 2025Article
- Multimorbidity and COVID-19 Outcomes in the Emergency Department: Is the Association Mediated by the Severity of the Condition at Admission?Journal of clinical medicine · 2024Article
- Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications.Brain, behavior, & immunity - health · 2024Article
- Prevalence of multiple long-term chronic conditions and associated disabilities among community-dwelling adults in Riyadh.Frontiers in public health · 2024Article
- Understanding the association of disability with multimorbidity, and healthcare utilization in India's older adult population: insights from cross-sectional evidence of SAGE-2.Frontiers in public health · 2024Article
- Association between multimorbidity and informal long-term care use in China: a nationwide cohort study.BMC geriatrics · 2023Article
- Environmental exposures in early-life and general health in childhood.Environmental health : a global access science source · 2023Article
- Observational
- The Associations of Individual and Subclasses of Nonesterified Fatty Acids With Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Life-course social connectedness: Comparing data-driven and theoretical classifications as predictors of functional limitations in adulthood.Advances in life course research · 2023Article
- Multimorbidity and Functional Disability among Older Adults: The Role of Inflammation and Glycemic Status - An Observational Longitudinal Study.Gerontology · 2023Observational
- The Mediating Role of Depression in Association Between Total Sleep Time and Instrumental Activities of Daily Living in China.International journal of public health · 2023Article
- The Association Between Cytomegalovirus and Disability by Race/Ethnicity and Sex: Results From the Health and Retirement Study.American journal of epidemiology · 2021Article
- Inflammation in multimorbidity and disability: An integrative review.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundUsing longitudinal data from the Survey of Mid-Life Development in the United States, this study examined the role of systemic inflammation in mediating the link between multimorbidity and increases in and onset of functional limitations over a 17-19 year follow-up period.
methodsParticipants completed questionnaire assessments of chronic conditions and functional limitations. Interleukin-6, C-reactive protein, and fibrinogen were assayed in serum. Structural equation models were used to predict increases in and onset of functional limitations associated with baseline multimorbidity status; mediation by inflammation was also determined.
resultsMultimorbidity ( DISCUSSION: These results show that inflammation, a nonspecific marker of multiple disease conditions, explains in part the degree to which multimorbidity is disabling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.