Evidence map›Paper›PMID 31452692›Full record

ArticleTherapeutic advances in medical oncology2019

Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer.

Ugo De Giorgi, Michal Mego, Emanuela Scarpi, Antonio Giordano, Mario Giuliano, Vicente Valero, Ricardo H Alvarez, Naoto T Ueno, Massimo Cristofanilli, James M Reuben

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in medical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04729647 (Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04729647 nacompletednot on this map

Immature Granulocyte Count and Delta Neutrophil Index as New Predictive Factors for Axillary Metastasis of Breast Cancer

TypeinterventionalSponsorKahramanmaras Sutcu Imam UniversityRan2015 to 2020Enrolled83ConditionsBreast Cancer, Breast Cancer InvasiveArmsMastectomy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  16. Circulating tumor cellsTranslational breast cancer research : a journal focusing on translational research in breast cancer · 2024
    Review
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  19. [Analysis of efficacy and prognosis of neoadjuvant chemotherapy and （or） surgery plus radiotherapy for hypopharyngeal squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Ugo De GiorgiDepartment of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Maroncelli 40, Meldola, 47014, Italy.ORCID https://orcid.org/0000-0001-7520-2908
Michal Mego2nd Department of Medical Oncology, National Cancer Institute, Bratislava, Slovak Republic.
Emanuela ScarpiBiostatistics and Clinical Trials Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy.
Antonio GiordanoDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Mario GiulianoDepartment of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Vicente ValeroDepartment of Breast Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Ricardo H AlvarezDepartment of Breast Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Naoto T UenoDepartment of Breast Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Massimo CristofanilliDepartment of Medicine-Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.
James M ReubenDepartment of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITFederico II University Hospital · ITMedical University of South Carolina · USNorthwestern University · USSlovak Medical University · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe retrospectively evaluated the correlation between a baseline measurement of circulating tumor cells (CTCs) and inflammation-based scores in patients with metastatic breast cancer (MBC).

methodsThe optimal value of inflammation-based scores as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) to predict survival was determined and compared with CTC <5 or ⩾5 per 7.5 ml of blood.

resultsIn the overall population of 516 women with MBC, CTCs correlated with peripheral blood monocytes (

conclusionsCTC and MLR are predictors of overall survival in MBC. CTC correlates with monocytes, in particular in triple-negative tumors.

Indexed as

breast cancercirculating tumor cellsCTCinflammationmonocytesprognosis

Identifiers

PMID31452692
PMCPMC6696837
OpenAlexW2967604243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.