Evidence map›Paper›PMID 31452688›Full record

ArticleTherapeutic advances in urology

Prostate volume index and prostatic chronic inflammation have an effect on tumor load at baseline random biopsies in patients with normal DRE and PSA values less than 10 ng/ml: results of 564 consecutive cases.

Antonio B Porcaro, Alessandro Tafuri, Marco Sebben, Aliasger Shakir, Giovanni Novella, Marco Pirozzi, Tania Processali, Riccardo Rizzetto, Nelia Amigoni, Leone Tiso and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Antonio B PorcaroDepartment of Urology, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126, Verona, Italy.ORCID https://orcid.org/0000-0002-7890-040X
Alessandro TafuriDepartment of Urology, University of Verona, Verona, Italy.
Marco SebbenDepartment of Urology, University of Verona, Verona, Italy.
Aliasger ShakirUSC Institute of Urology and Catherine and Joseph Aresty Department of Urology, University of Southern California, Los Angeles, CA, USA.
Giovanni NovellaDepartment of Urology, University of Verona, Verona, Italy.
Marco PirozziDepartment of Urology, University of Verona, Verona, Italy.
Tania ProcessaliDepartment of Urology, University of Verona, Verona, Italy.
Riccardo RizzettoDepartment of Urology, University of Verona, Verona, Italy.
Nelia AmigoniDepartment of Urology, University of Verona, Verona, Italy.
Leone TisoDepartment of Urology, University of Verona, Verona, Italy.
Clara CerratoDepartment of Urology, University of Verona, Verona, Italy.
Matteo BrunelliDepartment of Pathology, University of Verona, Verona, Italy.
Maria Angela CerrutoDepartment of Urology, University of Verona, Verona, Italy.
Filippo MiglioriniDepartment of Urology, University of Verona, Verona, Italy.
Salvatore SiracusanoDepartment of Urology, University of Verona, Verona, Italy.
Walter ArtibaniDepartment of Urology, University of Verona, Verona, Italy.
University of Verona · ITUniversity of Southern California · USAzienda Ospedaliera Universitaria Integrata Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the association of prostate volume index (PVI), defined as the ratio of the central transition zone volume (CTZV) to the peripheral zone volume (PZV), and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA) load in patients presenting with normal digital rectal exam (DRE) and prostate-specific antigen (PSA) ⩽ 10 ng/ml at baseline random biopsies.

methodsParameters evaluated included age, PSA, total prostate volume (TPV), PSA density (PSAD), PVI and PCI. All patients underwent 14 core transperineal randomized biopsies. We considered small and high PCA load patients with no more than three (limited tumor load) and greater than three (extensive tumor load) positive biopsy cores, respectively. The association of factors with the risk of PCA was evaluated by logistic regression analysis, utilizing different multivariate models.

results564 Caucasian patients were included. PCA and PCI were detected in 242 (42.9%) and 129 (22.9%) cases, respectively. On multivariate analysis, PVI and PCI were independent predictors of the risk of detecting limited or extensive tumor load. The risk of detecting extensive tumor load at baseline biopsies was increased by PSAD above the median and third quartile as well as PVI ⩽ 1 [odds ratio (OR)=1.971] but decreased by PCI (OR=0.185; 95% CI: 0.088-0.388).

conclusionsHigher PVI and the presence of PCI predicted decreased PCA risk in patients presenting with normal DRE, and a PSA ⩽ 10 ng/ml at baseline random biopsy. In this subset of patients, a PVI ⩽ or >1 is able to differentiate patients with PCA or PCI.

Indexed as

prostate biopsyprostate cancerprostate-specific antigenprostate tumor gradeprostate volume indexprostatic chronic inflammationtumor volume

Identifiers

PMID31452688
PMCPMC6696840
OpenAlexW2968267652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.