ArticleeLife2019
Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
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Who cites it
88 citing papers in PubMed, 137 citations in OpenAlex.
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- CAPHEINE, or Everything and the Kitchen Sink: A Workflow for Automating Selection Analyses Using HyPhy.Genome biology and evolution · 2026Article
- The Dual Role of Preexisting Immunity in Influenza: Protective Recall Versus Constraint of Novel Responses.Immunological reviews · 2026Review
- Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning.Cell reports methods · 2026Article
- CAPHEINE, or everything and the kitchen sink: a workflow for automating selection analyses using HyPhy.bioRxiv : the preprint server for biology · 2026Article
- Structural insights into antibody responses against influenza A virus in its natural reservoir.bioRxiv : the preprint server for biology · 2026Article
- Decoding epitope immunodominance in HIV Env using cryoEM and machine learning.bioRxiv : the preprint server for biology · 2026Article
- Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza haemagglutinin.Nature ecology & evolution · 2026Article
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- Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selection.bioRxiv : the preprint server for biology · 2026Article
- Variable and conserved B cell epitopes of GII.4 human noroviruses.Journal of virology · 2026Review
- Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selection.Virus evolution · 2026Article
- Article
- High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains.bioRxiv : the preprint server for biology · 2025Article
- Immunodominant antibodies against hemagglutinin in ferrets following infection with 2018 to 2019 influenza vaccine strains.NPJ vaccines · 2025Article
- Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitope.bioRxiv : the preprint server for biology · 2025Article
- Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025.bioRxiv : the preprint server for biology · 2025Article
- Deep Mutational Scanning in Immunology: Techniques and Applications.Pathogens (Basel, Switzerland) · 2025Review
- Variant scoring tools for deep mutational scanning.Molecular systems biology · 2025Review
- Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin.bioRxiv : the preprint server for biology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 2 countries.
Juhye M LeeBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Rachel EguiaBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Seth J ZostDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-6712-5076
Saket ChoudharyDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0001-5202-7633
Patrick C WilsonDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, United States.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-4039-5794
Terry Stevens-AyersVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
Aeron C HurtWHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Seema S LakdawalaDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, United States.ORCID 0000-0002-7679-2150
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jesse D BloomBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0003-1267-3408
Fred Hutch Cancer Center · USUniversity of Pennsylvania · USHoward Hughes Medical Institute · USPeter Doherty Institute · AUUniversity of Chicago · USUniversity of Pittsburgh · USUniversity of Southern California · USUniversity of Washington · US
Funding
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4MToward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WILSON, PATRICK CHRISTOPHER · 2012 to 2022
$17.6MUnderstanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2014 to 2018
$12.5MModeling the dynamics and evolution of immune responses to influenza virusesU19AI117891 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2015 to 2019
$8.4MReal-time tracking of virus evolution for vaccine strain selection and epidemiological investigationR35GM119774 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2016 to 2025
$4.1MImpact of prior influenza exposures on antibody repertoires to new viral strainsR01AI108686 · NIAID · WISTAR INSTITUTE · PI HENSLEY, SCOTT ERIC · 2014 to 2022
$3.7MThe effect of human pre-exposure history on antigenic drift of influenza virusesR01AI113047 · NIAID · WISTAR INSTITUTE · PI HENSLEY, SCOTT ERIC · 2014 to 2018
$2.5MHigh-throughput experiments to guide influenza vaccine strain selectionR01AI127893 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2016 to 2020
$2.1MProspectively characterizing the functional and antigenic effects of mutations to viral entry proteinsR01AI141707 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2018 to 2022
$2.1MFHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600kComprehensive antigenic mapping of seasonal influenza virusesF30AI136326 · NIAID · UNIVERSITY OF WASHINGTON · PI LEE, JUHYE MONICA · 2018 to 2020
$128kNIAID NIH HHS F30 AI136326NIAID NIH HHS P01 AI097092NIAID NIH HHS R01 AI108686NIAID NIH HHS R01 AI113047NIAID NIH HHS R01 AI127893NIAID NIH HHS R01 AI141707NIGMS NIH HHS R35 GM119774NIGMS NIH HHS T32 GM007266NIH HHS F30 AI136326NIH HHS HHSN272201400005CNIH HHS R01 AI108686NIH HHS R01 AI113047NIH HHS R01 AI141707NIH HHS R35 GM119774NIH HHS S10 OD020069NIH HHS U19 AI117891NIH HHS U54GM111274
Abstract
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza's major surface protein affect viral neutralization by polyclonal human sera. The serum of some individuals is so focused that it selects single mutations that reduce viral neutralization by over an order of magnitude. However, different viral mutations escape the sera of different individuals. This individual-to-individual variation in viral escape mutations is
Indexed as
Genetic VariationImmune EvasionMutationAnimalsAntibodies, ViralFerretsHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza, HumanOrthomyxoviridaeOrthomyxoviridae InfectionsSerumAntibodies, ViralHemagglutinin Glycoproteins, Influenza Virusantigenic driftdeep mutational scanningevolutionary biologyhemagglutininhumaninfectious diseaseinfluenza virusmicrobiologymutational antigenic profilingvirus
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