Evidence map›Paper›PMID 31452424›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2020

Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning.

Michael Eddleston, R Eddie Clutton, Matthew Taylor, Adrian Thompson, Franz Worek, Harald John, Horst Thiermann, Colin Scott

Open access · hybridAbstract read
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Michael EddlestonDepartment of Pharmacology, Toxicology & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-6857-3441
R Eddie CluttonDepartment of Anaesthesia, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.
Matthew TaylorCSIRO Biocatalysis & Synthetic Biology Team, Black Mountain Science and Innovation Park, Canberra, Australia.
Adrian ThompsonDepartment of Pharmacology, Toxicology & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Franz WorekBundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Harald JohnBundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Horst ThiermannBundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Colin ScottCSIRO Biocatalysis & Synthetic Biology Team, Black Mountain Science and Innovation Park, Canberra, Australia.
Institut für Pharmakologie und Toxikologie der BundeswehrUniversity of Edinburgh · GBCommonwealth Scientific and Industrial Research Organisation · AU

Funding

Medical Research Council MR/M024075/1Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAryldialkylphosphataseDisease Models, AnimalHumansInsecticidesMethyl ParathionOrganophosphate PoisoningSwineSwine, MiniatureAryldialkylphosphataseInsecticidesMethyl Parathionanimal modelantidotesenzymesOrganophosphorus insecticidestreatment

Identifiers

PMID31452424
PMCPMC7114914
OpenAlexW2971012729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.