ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020
Lung transplant outcomes are influenced by severity of neutropenia and granulocyte colony-stimulating factor treatment.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evaluation of Global Immune Biomarkers to Predict Infections in Lung Transplant Recipients.Clinical transplantation · 2026Article
- Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Article
- In silico perturbations provide multivariate interpretability in predicting post-lung transplant outcomes.Scientific reports · 2026Article
- Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Long-Term Outcomes Among Lung Transplant Recipients With High-Risk Cytomegalovirus Mismatch Managed With a Multimodality Regimen.Clinical transplantation · 2025Article
- An integrated sampling strategy for therapeutic mycophenolic acid monitoring in lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- CMV Infection Risk Factors and Viral Dynamics After Valganciclovir Prophylaxis: 10 Years of Experience in Lung Transplant Recipients.Microorganisms · 2024Article
- Impact of Neutropenia on Clinical Outcomes after Lung Transplantation.Medical sciences (Basel, Switzerland) · 2024Observational
- Donor age over 55 is associated with worse outcome in lung transplant recipients with idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2024Article
- Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients.Frontiers in transplantation · 2024Review
- Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study.Signal transduction and targeted therapy · 2023Article
- Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation.JCI insight · 2023Article
- Adaptive Immunosuppression in Lung Transplant Recipients Applying Complementary Biomarkers: The Zurich Protocol.Medicina (Kaunas, Lithuania) · 2023Article
- Case report: Use of granulocyte-colony stimulating factor as an immunomodulatory therapy in a patient with neuromyelitis optica spectrum disorder and comorbid immunodeficiency.Frontiers in neurology · 2023Article
- Short- and long-term impact of neutropenia within the first year after kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2021Article
- Factors associated with neutropenia post heart transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
- Impact of G-CSF Therapy on Leukopenia and Acute Rejection Following Kidney Transplantation.International journal of organ transplantation medicine · 2021Article
- Surveillance for acute cellular rejection after lung transplantation.Annals of translational medicine · 2020Review
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Authors and funding
9 authors.
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Abstract
Although neutropenia is a common complication after lung transplant, its relationship with recipient outcomes remains understudied. We evaluated a retrospective cohort of 228 adult lung transplant recipients between 2008 and 2013 to assess the association of neutropenia and granulocyte colony-stimulating factor (GCSF) treatment with outcomes. Neutropenia was categorized as mild (absolute neutrophil count 1000-1499), moderate (500-999), or severe (<500) and as a time-varying continuous variable. Associations with survival, acute rejection, and chronic lung allograft dysfunction (CLAD) were assessed with the use of Cox proportional hazards regression. GCSF therapy impact on survival, CLAD, and acute rejection development was analyzed by propensity score matching. Of 228 patients, 101 (42.1%) developed neutropenia. Recipients with severe neutropenia had higher mortality rates than those of recipients with no (adjusted hazard ratio [aHR] 2.97, 95% confidence interval [CI] 1.05-8.41, P = .040), mild (aHR 14.508, 95% CI 1.58-13.34, P = .018), or moderate (aHR 3.27, 95% CI 0.89-12.01, P = .074) neutropenia. Surprisingly, GCSF treatment was associated with a higher risk for CLAD in mildly neutropenic patients (aHR 3.49, 95% CI 0.93-13.04, P = .063), although it did decrease death risk in severely neutropenic patients (aHR 0.24, 95% CI 0.07-0.88, P = .031). Taken together, our data point to an important relationship between neutropenia severity and GCSF treatment in lung transplant outcomes.
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