ArticleHuman brain mapping2019
MR-based age-related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Quantitative MRI analysis of deep gray matter aging: Volumetric, T1/T2 ratio, and blood perfusion alterations.Neuroimage. Reports · 2026Article
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Biophysical simulation enables segmentation and nervous system atlas mapping for image first spatial omics.NPJ systems biology and applications · 2025Article
- The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Profiling disease experience in patients living with brain aneurysms by analyzing multimodal clinical data and quality of life measures.Scientific reports · 2025Article
- Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus.Brain structure & function · 2025Article
- Age-related volume decrease in subcortical gray matter is a part of healthy brain aging in men.Irish journal of medical science · 2025Article
- Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects.Metabolites · 2025Article
- Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.Brain communications · 2025Article
- Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Comparative MRI analysis of the forebrain of three sauropsida models.Brain structure & function · 2024Article
- Morphological characteristics of cerebellum, pons and thalamus in Reccurent isolated sleep paralysis - A pilot study.Frontiers in neuroanatomy · 2024Article
- Association of coffee consumption and striatal volume in patients with Parkinson's disease and healthy controls.CNS neuroscience & therapeutics · 2023Article
- Gestational age-related changes in relaxation times of neonatal brain by quantitative synthetic magnetic resonance imaging.Brain and behavior · 2023Article
- High spatial overlap but diverging age-related trajectories of cortical magnetic resonance imaging markers aiming to represent intracortical myelin and microstructure.Human brain mapping · 2023Article
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Multi-atlas thalamic nuclei segmentation on standard T1-weighed MRI with application to normal aging.Human brain mapping · 2023Article
- MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients.Frontiers in aging neuroscience · 2023Article
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11 authors.
Funding
Abstract
While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age-related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1-weighted/T2-weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18-83. In accordance with previous cross-sectional studies of adults, we observed age-related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age-related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U-shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.
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