ArticlePflugers Archiv : European journal of physiology2019
Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms.
Article in Pflugers Archiv : European journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Activation of ATP Consumption Is Necessary to Stimulate Glycogenolysis in Skeletal Muscle.International journal of molecular sciences · 2026Article
- Age-related changes in adrenergic regulation of contractility and redox status of glycolytic and oxidative skeletal muscles.GeroScience · 2026Article
- Cardiovascular response to anticipatory and reactionary postural perturbations in young adults.Experimental physiology · 2023Article
- The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise.Sports medicine and health science · 2023Review
- A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle.European journal of applied physiology · 2022Review
- MCU-complex-mediated mitochondrial calcium signaling is impaired in Barth syndrome.Human molecular genetics · 2022Article
- Skeletal muscle thermogenesis induction by exposure to predator odor.The Journal of experimental biology · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Fight or flight is a biologic phenomenon that involves activation of β-adrenoceptors in skeletal muscle. However, how force generation is enhanced through adrenergic activation in different muscle types is not fully understood. We studied the effects of isoproterenol (ISO, β-receptor agonist) on force generation and energy metabolism in isolated mouse soleus (SOL, oxidative) and extensor digitorum longus (EDL, glycolytic) muscles. Muscles were stimulated with isometric tetanic contractions and analyzed for metabolites and phosphorylase activity. Under conditions of maximal force production, ISO enhanced force generation markedly more in SOL (22%) than in EDL (8%). Similarly, during a prolonged tetanic contraction (30 s for SOL and 10 s for EDL), ISO-enhanced the force × time integral more in SOL (25%) than in EDL (3%). ISO induced marked activation of phosphorylase in both muscles in the basal state, which was associated with glycogenolysis (less in SOL than in EDL), and in EDL only, a significant decrease (16%) in inorganic phosphate (P
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