ReviewDiabetologia2019
Developmental undernutrition, offspring obesity and type 2 diabetes.
Review in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A systematic review and meta-analysis to assess the effect of hidden hunger on glycaemic control in patients with type 2 diabetes.Scientific reports · 2025Pooled it
- Effects of rapid growth on fasting insulin and insulin resistance: a system review and meta-analysis.European journal of clinical nutrition · 2021Pooled it
- Spatial heterogeneity and co-occurrence of childhood undernutrition in India: a joint analysis of stunting, anaemia and low birthweight.BMC public health · 2026Article
- The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.Annual review of nutrition · 2026Review
- Maternal Nutritional Status and Intrauterine Programming: Epigenetic Mechanisms and Their Impact on Offspring Health.Nutrients · 2026Review
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes.JAMA network open · 2025Article
- Ethnic diversity in precision medicine: a reality or an aspiration?Diabetologia · 2025Review
- Grandmaternal exercise improves the metabolic health of second-generation offspring generated from F1 females.Journal of sport and health science · 2025Article
- Factors Associated with Anthropometry Z-Scores in Exclusively Breastfed Infants Aged 0-6 Months in 10 Cities of China.Nutrients · 2025Article
- Association of Adiponectin and Resistin Gene Polymorphisms with Undernutrition Risk among Type 2 Diabetes Patients in Bosnia and Herzegovina.Iranian journal of public health · 2025Article
- Mid-Life Household Food Insecurity and Subsequent Memory Function and Rate of Decline in Rural South Africa, 2004-2022.Neuroepidemiology · 2025Article
- Epidemiology of overweight in under-five children in India: insights from National Family Health Survey.The British journal of nutrition · 2024Article
- Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at late adulthood.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways.Journal of cachexia, sarcopenia and muscle · 2024Review
- The association of hypertension among married Indian couples: a nationally representative cross-sectional study.Scientific reports · 2024Article
- Article
- Associations of infant feeding practices with abdominal and hepatic fat measures in childhood in the longitudinal Healthy Start Study.The American journal of clinical nutrition · 2024Article
- Impact of prenatal maternal dietary exclusion on childhood obesity and overweight risk.PloS one · 2024Article
- The True Price of External Health Effects from Food Consumption.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The Developmental Origins of Health and Disease (DOHaD) paradigm posits that a mismatch between circumstances at or around conception and in later life leads to metabolic dysregulation and the development of obesity and diabetes. In this review we highlight three strands of evidence: prospective studies of patterns of growth from birth to adulthood, historical studies of exposure to famine at defined points during gestation and early life, and nutrition intervention studies. We conclude that, while much is still unknown, it is becoming clearer that the combination of early-life undernutrition and later development of obesity is associated with increased risk of diabetes. There is a need to support public health programmes aimed at intergenerational (primordial) prevention of diabetes and other non-communicable disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.