ArticleNature materials2020
Actomyosin controls planarity and folding of epithelia in response to compression.
Article in Nature materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- A biohybrid system to reconstruct epithelial morphomechanicsMaterials today. Bio · 2026Article
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.Nature communications · 2025Article
- Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.Communications biology · 2025Article
- Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells.bioRxiv : the preprint server for biology · 2025Article
- Article
- An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility.Nature communications · 2024Article
- Rupture strength of living cell monolayers.Nature materials · 2024Article
- Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition.Nature communications · 2024Article
- Magnetic Membranes for Cell Growth Under Curved and Reversible Deformations.Small science · 2024Article
- Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition.bioRxiv : the preprint server for biology · 2024Article
- Active viscoelastic models for cell and tissue mechanics.Royal Society open science · 2024Article
- Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina.Development (Cambridge, England) · 2024Article
- Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization.Nature physics · 2024Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Cell size and actin architecture determine force generation in optogenetically activated cells.Biophysical journal · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Collective curvature sensing and fluidity in three-dimensional multicellular systems.Nature physics · 2022Article
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8 authors.
Funding
Abstract
Throughout embryonic development and adult life, epithelia are subjected to compressive deformations. While these have been shown to trigger mechanosensitive responses such as cell extrusion and differentiation, which span tens of minutes, little is known about how epithelia adapt to compression over shorter timescales. Here, using suspended epithelia, we uncover the immediate response of epithelial tissues to the application of in-plane compressive strains (5-80%). We show that fast compression induces tissue buckling followed by actomyosin-dependent tissue flattening that erases the buckle within tens of seconds, in both mono- and multi-layered epithelia. Strikingly, we identify a well-defined limit to this response, so that stable folds form in the tissue when compressive strains exceed a 'buckling threshold' of ~35%. A combination of experiment and modelling shows that this behaviour is orchestrated by adaptation of the actomyosin cytoskeleton as it re-establishes tissue tension following compression. Thus, tissue pre-tension allows epithelia to both buffer against deformation and sets their ability to form and retain folds during morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.